AOC3

Amine oxidase, copper containing 3 (vascular adhesion protein 1)
PDB rendering based on 1pu4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1pu4​, 1us1​, 2c10​, 2c11​
Identifiers
Symbols	AOC3 ; HPAO; SSAO; VAP-1; VAP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2770
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amine oxidase, copper containing 3 (vascular adhesion protein 1), also known as AOC3, is a human gene.

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has functional monoamine oxidase activity. A pseudogene for this gene has been described and is located approximately 9-kb downstream.

Further reading

• Lalor PF, Lai WK, Curbishley SM; et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo". World J. Gastroenterol. 12 (34): 5429–39. PMID 17006978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bustelo XR, Barbacid M (1992). "Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells". Science. 256 (5060): 1196–9. PMID 1375396.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang X, McIntire WS (1997). "Cloning and sequencing of a copper-containing, topa quinone-containing monoamine oxidase from human placenta". Gene. 179 (2): 279–86. PMID 8972912.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith DJ, Salmi M, Bono P; et al. (1998). "Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule". J. Exp. Med. 188 (1): 17–27. PMID 9653080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lalor PF, Edwards S, McNab G; et al. (2002). "Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells". J. Immunol. 169 (2): 983–92. PMID 12097405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salmi M, Stolen C, Jousilahti P; et al. (2003). "Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes". Am. J. Pathol. 161 (6): 2255–62. PMID 12466139.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Singh B, Tschernig T, van Griensven M; et al. (2003). "Expression of vascular adhesion protein-1 in normal and inflamed mice lungs and normal human lungs". Virchows Arch. 442 (5): 491–5. doi:10.1007/s00428-003-0802-6. PMID 12700900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Q, Mashima Y, Noda S; et al. (2004). "Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina". Gene. 318: 45–53. PMID 14585497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conklin DJ, Cowley HR, Wiechmann RJ; et al. (2004). "Vasoactive effects of methylamine in isolated human blood vessels: role of semicarbazide-sensitive amine oxidase, formaldehyde, and hydrogen peroxide". Am. J. Physiol. Heart Circ. Physiol. 286 (2): H667–76. doi:10.1152/ajpheart.00690.2003. PMID 14715500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koskinen K, Vainio PJ, Smith DJ; et al. (2004). "Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1)". Blood. 103 (9): 3388–95. doi:10.1182/blood-2003-09-3275. PMID 14726375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olivé M, Unzeta M, Moreno D, Ferrer I (2004). "Overexpression of semicarbazide-sensitive amine oxidase in human myopathies". Muscle Nerve. 29 (2): 261–6. doi:10.1002/mus.10550. PMID 14755492.CS1 maint: Multiple names: authors list (link)
• Forster-Horváth C, Döme B, Paku S; et al. (2005). "Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma". Melanoma Res. 14 (2): 135–40. PMID 15057044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMID 15242332.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boomsma F, Pedersen-Bjergaard U, Agerholm-Larsen B; et al. (2005). "Association between plasma activities of semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in patients with type 1 diabetes mellitus". Diabetologia. 48 (5): 1002–7. doi:10.1007/s00125-005-1716-4. PMID 15830186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li HY, Lee WJ, Chen MJ, Chuang LM (2005). "Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity". Obes. Res. 13 (5): 855–61. PMID 15919838.CS1 maint: Multiple names: authors list (link)
• Airenne TT, Nymalm Y, Kidron H; et al. (2005). "Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications". Protein Sci. 14 (8): 1964–74. doi:10.1110/ps.051438105. PMID 16046623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)