ANXA4

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Annexin A4
PBB Protein ANXA4 image.jpg
PDB rendering based on 1ann.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols ANXA4 ; ANX4; DKFZp686H02120; MGC75105; PIG28
External IDs OMIM: 106491 MGI88030 HomoloGene68164
RNA expression pattern
PBB GE ANXA4 201302 at tn.png
PBB GE ANXA4 201301 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 307
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 11746

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000196975
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000029994

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P09525
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3UCL0

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_001153 (mRNA)
NP_001144 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_013471 (mRNA)
NP_038499 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 2: 69.8 - 69.91 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 6: 86.7 -  86.73 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Annexin A4, also known as ANXA4, is a human gene.[1]

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.[1]

References

  1. 1.0 1.1 "Entrez Gene: ANXA4 annexin A4".

Further reading

  • Tait JF, Smith C, Frankenberry DA; et al. (1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. PMID 1346776.
  • Römisch J, Heimburger N (1990). "Purification and characterization of six annexins from human placenta". Biol. Chem. Hoppe-Seyler. 371 (5): 383–8. PMID 2143074.
  • Römisch J, Grote M, Weithmann KU; et al. (1991). "Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins". Biochem. J. 272 (1): 223–9. PMID 2148260.
  • Freemont PS, Driessen HP, Verbi W, Crumpton MJ (1991). "Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV". J. Mol. Biol. 216 (2): 219–21. PMID 2254922.
  • Hauptmann R, Maurer-Fogy I, Krystek E; et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. PMID 2530088.
  • Grundmann U, Amann E, Abel KJ, Küpper HA (1988). "Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family". Behring Inst. Mitt. (82): 59–67. PMID 2970257.
  • Ahn NG, Teller DC, Bienkowski MJ; et al. (1989). "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor". J. Biol. Chem. 263 (35): 18657–63. PMID 2974032.
  • Tait JF, Sakata M, McMullen BA; et al. (1989). "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family". Biochemistry. 27 (17): 6268–76. PMID 2975506.
  • Sjölin C, Stendahl O, Dahlgren C (1994). "Calcium-induced translocation of annexins to subcellular organelles of human neutrophils". Biochem. J. 300 ( Pt 2): 325–30. PMID 8002935.
  • Kojima K, Yamamoto K, Irimura T; et al. (1996). "Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids". J. Biol. Chem. 271 (13): 7679–85. PMID 8631806.
  • Davis AJ, Butt JT, Walker JH; et al. (1996). "The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP". J. Biol. Chem. 271 (40): 24333–6. PMID 8798684.
  • Satoh A, Takayama E, Kojima K; et al. (1997). "Expression of carbohydrate-binding protein p33/41 in human tumor cell lines". J. Biochem. 119 (2): 346–53. PMID 8882729.
  • Satoh A, Takayama E, Kojima K; et al. (1997). "Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17". Biol. Pharm. Bull. 20 (3): 224–9. PMID 9084877.
  • Dreier R, Schmid KW, Gerke V, Riehemann K (1998). "Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study". Histochem. Cell Biol. 110 (2): 137–48. PMID 9720986.
  • Chow A, Davis AJ, Gawler DJ (2000). "Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain". FEBS Lett. 469 (1): 88–92. PMID 10708762.
  • Han EK, Tahir SK, Cherian SP; et al. (2000). "Modulation of paclitaxel resistance by annexin IV in human cancer cell lines". Br. J. Cancer. 83 (1): 83–8. doi:10.1054/bjoc.2000.1311. PMID 10883672.
  • Radau B, Otto A, Müller EC, Westermann P (2001). "Protein kinase C alpha-dependent phosphorylation of Golgi proteins". Electrophoresis. 21 (13): 2684–7. doi:10.1002/1522-2683(20000701)21:13<2684::AID-ELPS2684>3.0.CO;2-G. PMID 10949146.
  • Gerner C, Frohwein U, Gotzmann J; et al. (2001). "The Fas-induced apoptosis analyzed by high throughput proteome analysis". J. Biol. Chem. 275 (50): 39018–26. doi:10.1074/jbc.M006495200. PMID 10978337.
  • Tsujii-Hayashi Y, Kitahara M, Yamagaki T; et al. (2003). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". J. Biol. Chem. 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

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