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{{Infobox_gene}}
{{PBB_Controls
'''Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase''' is an [[enzyme]] that in humans is encoded by the ''ALG6'' [[gene]].<ref name="pmid10359825">{{cite journal | vauthors = Imbach T, Burda P, Kuhnert P, Wevers RA, Aebi M, Berger EG, Hennet T | title = A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 12 | pages = 6982–7 | date = Jun 1999 | pmid = 10359825 | pmc = 22030 | doi = 10.1073/pnas.96.12.6982 }}</ref><ref name="pmid11875054">{{cite journal | vauthors = Westphal V, Kjaergaard S, Schollen E, Martens K, Grunewald S, Schwartz M, Matthijs G, Freeze HH | title = A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency | journal = Human Molecular Genetics | volume = 11 | issue = 5 | pages = 599–604 | date = Mar 2002 | pmid = 11875054 | pmc = | doi = 10.1093/hmg/11.5.599 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALG6 asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29929| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
| HGNCid = 23157
| Symbol = ALG6
| AltSymbols =;
| OMIM = 604566
| ECnumber = 
| Homologene = 6920
| MGIid = 2444031
| GeneAtlas_image1 = PBB_GE_ALG6_219649_at_tn.png
| Function = {{GNF_GO|id=GO:0004576 |text = oligosaccharyl transferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0046527 |text = glucosyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006487 |text = protein amino acid N-linked glycosylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29929
    | Hs_Ensembl = ENSG00000088035
    | Hs_RefseqProtein = NP_037471
    | Hs_RefseqmRNA = NM_013339
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 63605849
    | Hs_GenLoc_end = 63676821
    | Hs_Uniprot = Q9Y672
    | Mm_EntrezGene = 320438
    | Mm_Ensembl = ENSMUSG00000073792
    | Mm_RefseqmRNA = XM_620085
    | Mm_RefseqProtein = XP_620085
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 99207683
    | Mm_GenLoc_end = 99255475
    | Mm_Uniprot = 
  }}
}}
'''Asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)''', also known as '''ALG6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ALG6 asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29929| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the ALG6/ALG8 [[glucosyltransferase]] family. The encoded protein catalyzes the addition of the first [[glucose]] residue to the growing lipid-linked [[oligosaccharide]] precursor of N-linked [[glycosylation]]. Mutations in this gene are associated with [[congenital disorders of glycosylation]] type Ic.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic.<ref name="entrez">{{cite web | title = Entrez Gene: ALG6 asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29929| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Burda P, Borsig L, de Rijk-van Andel J, Wevers R, Jaeken J, Carchon H, Berger EG, Aebi M | title = A novel carbohydrate-deficient glycoprotein syndrome characterized by a deficiency in glucosylation of the dolichol-linked oligosaccharide | journal = The Journal of Clinical Investigation | volume = 102 | issue = 4 | pages = 647–52 | date = Aug 1998 | pmid = 9710431 | pmc = 508925 | doi = 10.1172/JCI2266 }}
| citations =
* {{cite journal | vauthors = Körner C, Knauer R, Holzbach U, Hanefeld F, Lehle L, von Figura K | title = Carbohydrate-deficient glycoprotein syndrome type V: deficiency of dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 22 | pages = 13200–5 | date = Oct 1998 | pmid = 9789065 | pmc = 23759 | doi = 10.1073/pnas.95.22.13200 | url = http://goedoc.uni-goettingen.de/goescholar/bitstream/handle/1/3444/319.%20Carbohydrate-deficient%20glycoprotein%20syndrome%20type%20V%20....pdf?sequence=1 }}
*{{cite journal | author=Burda P, Borsig L, de Rijk-van Andel J, ''et al.'' |title=A novel carbohydrate-deficient glycoprotein syndrome characterized by a deficiency in glucosylation of the dolichol-linked oligosaccharide. |journal=J. Clin. Invest. |volume=102 |issue= 4 |pages= 647-52 |year= 1998 |pmid= 9710431 |doi= }}
* {{cite journal | vauthors = Imbach T, Grünewald S, Schenk B, Burda P, Schollen E, Wevers RA, Jaeken J, de Klerk JB, Berger EG, Matthijs G, Aebi M, Hennet T | title = Multi-allelic origin of congenital disorder of glycosylation (CDG)-Ic | journal = Human Genetics | volume = 106 | issue = 5 | pages = 538–45 | date = May 2000 | pmid = 10914684 | doi = 10.1007/s004390050022 }}
*{{cite journal | author=Körner C, Knauer R, Holzbach U, ''et al.'' |title=Carbohydrate-deficient glycoprotein syndrome type V: deficiency of dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13200-5 |year= 1998 |pmid= 9789065 |doi= }}
* {{cite journal | vauthors = Westphal V, Schottstädt C, Marquardt T, Freeze HH | title = Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic | journal = Molecular Genetics and Metabolism | volume = 70 | issue = 3 | pages = 219–23 | date = Jul 2000 | pmid = 10924277 | doi = 10.1006/mgme.2000.3017 }}
*{{cite journal  | author=Imbach T, Burda P, Kuhnert P, ''et al.'' |title=A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6982-7 |year= 1999 |pmid= 10359825 |doi=  }}
* {{cite journal | vauthors = Westphal V, Murch S, Kim S, Srikrishna G, Winchester B, Day R, Freeze HH | title = Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation | journal = The American Journal of Pathology | volume = 157 | issue = 6 | pages = 1917–25 | date = Dec 2000 | pmid = 11106564 | pmc = 1885788 | doi = 10.1016/S0002-9440(10)64830-4 }}
*{{cite journal | author=Imbach T, Grünewald S, Schenk B, ''et al.'' |title=Multi-allelic origin of congenital disorder of glycosylation (CDG)-Ic. |journal=Hum. Genet. |volume=106 |issue= 5 |pages= 538-45 |year= 2000 |pmid= 10914684 |doi= }}
* {{cite journal | vauthors = de Lonlay P, Seta N, Barrot S, Chabrol B, Drouin V, Gabriel BM, Journel H, Kretz M, Laurent J, Le Merrer M, Leroy A, Pedespan D, Sarda P, Villeneuve N, Schmitz J, van Schaftingen E, Matthijs G, Jaeken J, Korner C, Munnich A, Saudubray JM, Cormier-Daire V | title = A broad spectrum of clinical presentations in congenital disorders of glycosylation I: a series of 26 cases | journal = Journal of Medical Genetics | volume = 38 | issue = 1 | pages = 14–9 | date = Jan 2001 | pmid = 11134235 | pmc = 1734729 | doi = 10.1136/jmg.38.1.14 }}
*{{cite journal | author=Westphal V, Schottstädt C, Marquardt T, Freeze HH |title=Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic. |journal=Mol. Genet. Metab. |volume=70 |issue= 3 |pages= 219-23 |year= 2000 |pmid= 10924277 |doi= 10.1006/mgme.2000.3017 }}
* {{cite journal | vauthors = Vuillaumier-Barrot S, Le Bizec C, Durand G, Seta N | title = The T911C (F304S) substitution in the human ALG6 gene is a common polymorphism and not a causal mutation of CDG-Ic | journal = Journal of Human Genetics | volume = 46 | issue = 9 | pages = 547–8 | year = 2001 | pmid = 11558905 | doi = 10.1007/s100380170038 }}
*{{cite journal | author=Westphal V, Murch S, Kim S, ''et al.'' |title=Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation. |journal=Am. J. Pathol. |volume=157 |issue= 6 |pages= 1917-25 |year= 2001 |pmid= 11106564 |doi= }}
* {{cite journal | vauthors = Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P | title = Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate | journal = Molecular Biology and Evolution | volume = 19 | issue = 9 | pages = 1451–63 | date = Sep 2002 | pmid = 12200473 | doi = 10.1093/oxfordjournals.molbev.a004208 }}
*{{cite journal | author=de Lonlay P, Seta N, Barrot S, ''et al.'' |title=A broad spectrum of clinical presentations in congenital disorders of glycosylation I: a series of 26 cases. |journal=J. Med. Genet. |volume=38 |issue= 1 |pages= 14-9 |year= 2001 |pmid= 11134235 |doi= }}
* {{cite journal | vauthors = Schollen E, Martens K, Geuzens E, Matthijs G | title = DHPLC analysis as a platform for molecular diagnosis of congenital disorders of glycosylation (CDG) | journal = European Journal of Human Genetics | volume = 10 | issue = 10 | pages = 643–8 | date = Oct 2002 | pmid = 12357336 | doi = 10.1038/sj.ejhg.5200858 }}
*{{cite journal | author=Vuillaumier-Barrot S, Le Bizec C, Durand G, Seta N |title=The T911C (F304S) substitution in the human ALG6 gene is a common polymorphism and not a causal mutation of CDG-Ic. |journal=J. Hum. Genet. |volume=46 |issue= 9 |pages= 547-8 |year= 2001 |pmid= 11558905 |doi= }}
* {{cite journal | vauthors = Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A | title = Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis | journal = Experimental Cell Research | volume = 288 | issue = 1 | pages = 35–50 | date = Aug 2003 | pmid = 12878157 | doi = 10.1016/S0014-4827(03)00130-7 }}
*{{cite journal  | author=Westphal V, Kjaergaard S, Schollen E, ''et al.'' |title=A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency. |journal=Hum. Mol. Genet. |volume=11 |issue= 5 |pages= 599-604 |year= 2002 |pmid= 11875054 |doi=  }}
* {{cite journal | vauthors = Westphal V, Xiao M, Kwok PY, Freeze HH | title = Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic | journal = Human Mutation | volume = 22 | issue = 5 | pages = 420–1 | date = Nov 2003 | pmid = 14517965 | doi = 10.1002/humu.9195 }}
*{{cite journal | author=Oriol R, Martinez-Duncker I, Chantret I, ''et al.'' |title=Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. |journal=Mol. Biol. Evol. |volume=19 |issue= 9 |pages= 1451-63 |year= 2003 |pmid= 12200473 |doi= }}
* {{cite journal | vauthors = Eklund EA, Sun L, Yang SP, Pasion RM, Thorland EC, Freeze HH | title = Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation | journal = Biochemical and Biophysical Research Communications | volume = 339 | issue = 3 | pages = 755–60 | date = Jan 2006 | pmid = 16321363 | doi = 10.1016/j.bbrc.2005.11.073 }}
*{{cite journal | author=Schollen E, Martens K, Geuzens E, Matthijs G |title=DHPLC analysis as a platform for molecular diagnosis of congenital disorders of glycosylation (CDG). |journal=Eur. J. Hum. Genet. |volume=10 |issue= 10 |pages= 643-8 |year= 2003 |pmid= 12357336 |doi= 10.1038/sj.ejhg.5200858 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Imabayashi H, Mori T, Gojo S, ''et al.'' |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35-50 |year= 2003 |pmid= 12878157 |doi= }}
*{{cite journal | author=Westphal V, Xiao M, Kwok PY, Freeze HH |title=Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic. |journal=Hum. Mutat. |volume=22 |issue= 5 |pages= 420-1 |year= 2004 |pmid= 14517965 |doi= 10.1002/humu.9195 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Eklund EA, Sun L, Yang SP, ''et al.'' |title=Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation. |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue= 3 |pages= 755-60 |year= 2006 |pmid= 16321363 |doi= 10.1016/j.bbrc.2005.11.073 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1332/  GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]
* {{UCSC gene info|ALG6}}
 
{{Glycosyltransferases}}
 
 
{{gene-1-stub}}

Latest revision as of 14:54, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase is an enzyme that in humans is encoded by the ALG6 gene.[1][2][3]

Function

This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic.[3]

References

  1. ↑ Imbach T, Burda P, Kuhnert P, Wevers RA, Aebi M, Berger EG, Hennet T (Jun 1999). "A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6982–7. doi:10.1073/pnas.96.12.6982. PMC 22030. PMID 10359825.
  2. ↑ Westphal V, Kjaergaard S, Schollen E, Martens K, Grunewald S, Schwartz M, Matthijs G, Freeze HH (Mar 2002). "A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency". Human Molecular Genetics. 11 (5): 599–604. doi:10.1093/hmg/11.5.599. PMID 11875054.
  3. ↑ 3.0 3.1 "Entrez Gene: ALG6 asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)".

Further reading

External links


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