ALCAM

Revision as of 19:16, 8 November 2017 by JCW-CleanerBot (talk) (task using AWB)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[1][2] It is also called CD166 (cluster of differentiation 166), MEMD,[3] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands.[citation needed] CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma.[3] CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.[citation needed]

Recently, CD166 has also been used as a potential cancer stem cell marker.[citation needed]


References

  1. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
  2. "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule".
  3. 3.0 3.1 Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)". Am. J. Pathol. 152 (3): 805–13. PMC 1858405. PMID 9502422.

Further reading

External links



Linked-in.jpg