AKR1C1

Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
PDB rendering based on 1ihi.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ihi​, 1j96​, 1mrq​, 1xjb​, 2hdj​
Identifiers
Symbols	AKR1C1 ; C9; 2-ALPHA-HSD; 20-ALPHA-HSD; DD1; DDH; DDH1; H-37; HAKRC; MBAB; MGC8954; DD; AKR1C-pseudo; BABP; DD2; DDH2; HAKRD; HBAB; MCDR2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 84695
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), also known as AKR1C1, is a human gene.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Further reading

• Ciaccio PJ, Jaiswal AK, Tew KD (1994). "Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics". J. Biol. Chem. 269 (22): 15558–62. PMID 7515059.CS1 maint: Multiple names: authors list (link)
• Khanna M, Qin KN, Cheng KC (1995). "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans". J. Steroid Biochem. Mol. Biol. 53 (1–6): 41–6. PMID 7626489.CS1 maint: Multiple names: authors list (link)
• Khanna M, Qin KN, Klisak I; et al. (1995). "Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization". Genomics. 25 (2): 588–90. PMID 7789999.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ciaccio PJ, Tew KD (1994). "cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase". Biochim. Biophys. Acta. 1186 (1–2): 129–32. PMID 8011662.
• Lou H, Hammond L, Sharma V; et al. (1994). "Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding". J. Biol. Chem. 269 (11): 8416–22. PMID 8132567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deyashiki Y, Ogasawara A, Nakayama T; et al. (1994). "Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder". Biochem. J. 299 ( Pt 2): 545–52. PMID 8172617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qin KN, New MI, Cheng KC (1994). "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase". J. Steroid Biochem. Mol. Biol. 46 (6): 673–9. PMID 8274401.CS1 maint: Multiple names: authors list (link)
• Stolz A, Hammond L, Lou H; et al. (1993). "cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family". J. Biol. Chem. 268 (14): 10448–57. PMID 8486699.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hara A, Matsuura K, Tamada Y; et al. (1996). "Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells". Biochem. J. 313 ( Pt 2): 373–6. PMID 8573067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'connor T, Ireland LS, Harrison DJ, Hayes JD (1999). "Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members". Biochem. J. 343 Pt 2: 487–504. PMID 10510318.CS1 maint: Multiple names: authors list (link)
• Nishizawa M, Nakajima T, Yasuda K; et al. (2000). "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes Cells. 5 (2): 111–25. PMID 10672042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Dufort I, Rheault P, Luu-The V (2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". J. Mol. Endocrinol. 25 (2): 221–8. PMID 11013348.CS1 maint: Multiple names: authors list (link)
• Nahoum V, Gangloff A, Legrand P; et al. (2001). "Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution". J. Biol. Chem. 276 (45): 42091–8. doi:10.1074/jbc.M105610200. PMID 11514561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen CY, Hsu CP, Hsu NY; et al. (2002). "Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer". Oncol. Rep. 9 (3): 515–9. PMID 11956619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang MD, Wu CC, Chiou SH; et al. (2003). "Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma". Oncol. Rep. 10 (2): 271–6. PMID 12579257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakajima T, Yasuda K, Nishizawa M; et al. (2003). "Expression of 20alpha-hydroxysteroid dehydrogenase mRNA in human endometrium and decidua". Endocr. J. 50 (1): 105–11. PMID 12733716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Couture JF, Legrand P, Cantin L; et al. (2003). "Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids". J. Mol. Biol. 331 (3): 593–604. PMID 12899831.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Agapova OA, Yang P, Wang WH; et al. (2003). "Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes". Neurobiol. Dis. 14 (1): 63–73. PMID 13678667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)