AKR1B1

Aldo-keto reductase family 1, member B1 (aldose reductase)
File:PBB Protein AKR1B1 image.jpg PDB rendering based on 1abn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1abn​, 1ads​, 1az1​, 1az2​, 1ef3​, 1el3​, 1iei​, 1mar​, 1pwl​, 1pwm​, 1t40​, 1t41​, 1us0​, 1x96​, 1x97​, 1x98​, 1xgd​, 1z3n​, 1z89​, 1z8a​, 2acq​, 2acr​, 2acs​, 2acu​, 2agt​, 2dux​, 2duz​, 2dv0​, 2f2k​, 2fz8​, 2fz9​, 2fzb​, 2fzd​, 2hv5​, 2hvn​, 2hvo​, 2i16​, 2i17​, 2ikg​, 2ikh​, 2iki​, 2ikj​, 2ine​, 2inz​, 2ipw​, 2iq0​, 2iqd​, 2is7​, 2isf​, 2j8t​, 2nvc​, 2nvd​, 2pev​, 2pf8​, 2pfh​
Identifiers
Symbols	AKR1B1 ; ADR; ALDR1; AR; MGC1804
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68193
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Aldo-keto reductase family 1, member B1 (aldose reductase), also known as AKR1B1, is a human gene.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. There are a few putative pseudogenes for this gene, and one of them has been confirmed and mapped to chromosome 3.

Further reading

• Borhani DW, Harter TM, Petrash JM (1992). "The crystal structure of the aldose reductase.NADPH binary complex". J. Biol. Chem. 267 (34): 24841–7. PMID 1447221.CS1 maint: Multiple names: authors list (link)
• Wilson DK, Bohren KM, Gabbay KH, Quiocho FA (1992). "An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications". Science. 257 (5066): 81–4. PMID 1621098.CS1 maint: Multiple names: authors list (link)
• Graham A, Heath P, Morten JE, Markham AF (1991). "The human aldose reductase gene maps to chromosome region 7q35". Hum. Genet. 86 (5): 509–14. PMID 1901827.CS1 maint: Multiple names: authors list (link)
• Graham A, Brown L, Hedge PJ; et al. (1991). "Structure of the human aldose reductase gene". J. Biol. Chem. 266 (11): 6872–7. PMID 1901857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grundmann U, Bohn H, Obermeier R, Amann E (1990). "Cloning and prokaryotic expression of a biologically active human placental aldose reductase". DNA Cell Biol. 9 (3): 149–57. PMID 2111143.CS1 maint: Multiple names: authors list (link)
• Nishimura C, Matsuura Y, Kokai Y; et al. (1990). "Cloning and expression of human aldose reductase". J. Biol. Chem. 265 (17): 9788–92. PMID 2112546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morjana NA, Lyons C, Flynn TG (1989). "Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine". J. Biol. Chem. 264 (5): 2912–9. PMID 2492527.CS1 maint: Multiple names: authors list (link)
• Bohren KM, Bullock B, Wermuth B, Gabbay KH (1989). "The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases". J. Biol. Chem. 264 (16): 9547–51. PMID 2498333.CS1 maint: Multiple names: authors list (link)
• Chung S, LaMendola J (1989). "Cloning and sequence determination of human placental aldose reductase gene". J. Biol. Chem. 264 (25): 14775–7. PMID 2504709.
• Graham A, Hedge PJ, Powell SJ; et al. (1989). "Nucleotide sequence of cDNA for human aldose reductase". Nucleic Acids Res. 17 (20): 8368. PMID 2510130.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akagi Y, Kador PF, Kuwabara T, Kinoshita JH (1984). "Aldose reductase localization in human retinal mural cells". Invest. Ophthalmol. Vis. Sci. 24 (11): 1516–9. PMID 6417042.CS1 maint: Multiple names: authors list (link)
• Ko BC, Lam KS, Wat NM, Chung SS (1995). "An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients". Diabetes. 44 (7): 727–32. PMID 7789640.CS1 maint: Multiple names: authors list (link)
• Wilson DK, Tarle I, Petrash JM, Quiocho FA (1993). "Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 9847–51. PMID 8234324.CS1 maint: Multiple names: authors list (link)
• Tarle I, Borhani DW, Wilson DK; et al. (1994). "Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110". J. Biol. Chem. 268 (34): 25687–93. PMID 8245005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Robinson B, Hunsaker LA, Stangebye LA, Vander Jagt DL (1994). "Aldose and aldehyde reductases from human kidney cortex and medulla". Biochim. Biophys. Acta. 1203 (2): 260–6. PMID 8268209.CS1 maint: Multiple names: authors list (link)
• Jaquinod M, Potier N, Klarskov K; et al. (1994). "Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes". Eur. J. Biochem. 218 (3): 893–903. PMID 8281941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu SQ, Bhatnagar A, Ansari NH, Srivastava SK (1993). "Identification of the reactive cysteine residue in human placenta aldose reductase". Biochim. Biophys. Acta. 1164 (3): 268–72. PMID 8343525.CS1 maint: Multiple names: authors list (link)
• Nishimura C, Furue M, Ito T; et al. (1993). "Quantitative determination of human aldose reductase by enzyme-linked immunosorbent assay. Immunoassay of human aldose reductase". Biochem. Pharmacol. 46 (1): 21–8. PMID 8347133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato S, Lin LR, Reddy VN, Kador PF (1993). "Aldose reductase in human retinal pigment epithelial cells". Exp. Eye Res. 57 (2): 235–41. doi:10.1006/exer.1993.1119. PMID 8405190.CS1 maint: Multiple names: authors list (link)
• Ferraretto A, Negri A, Giuliani A; et al. (1993). "Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress". Biochim. Biophys. Acta. 1175 (3): 283–8. PMID 8435445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)