AKAP3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''A-kinase anchor protein 3''' is an [[enzyme]] that in humans is encoded by the ''AKAP3'' [[gene]].<ref name="pmid10334916">{{cite journal | vauthors = Lefevre A, Duquenne C, Rousseau-Merck MF, Rogier E, Finaz C | title = Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition | journal = Biochemical and Biophysical Research Communications | volume = 259 | issue = 1 | pages = 60–6 | date = May 1999 | pmid = 10334916 | pmc =  | doi = 10.1006/bbrc.1999.0728 }}</ref><ref name="pmid10319321">{{cite journal | vauthors = Vijayaraghavan S, Liberty GA, Mohan J, Winfrey VP, Olson GE, Carr DW | title = Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein | journal = Molecular Endocrinology | volume = 13 | issue = 5 | pages = 705–17 | date = May 1999 | pmid = 10319321 | pmc =  | doi = 10.1210/mend.13.5.0278 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10566| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 3
| HGNCid = 373
| Symbol = AKAP3
| AltSymbols =; AKAP110; FSP95; PRKA3; SOB1
| OMIM = 604689
| ECnumber = 
| Homologene = 4688
| MGIid = 1341149
| GeneAtlas_image1 = PBB_GE_AKAP3_207344_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0051018 |text = protein kinase A binding}}
| Component = {{GNF_GO|id=GO:0009434 |text = microtubule-based flagellum}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0007340 |text = acrosome reaction}} {{GNF_GO|id=GO:0008104 |text = protein localization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10566
    | Hs_Ensembl = ENSG00000111254
    | Hs_RefseqProtein = NP_006413
    | Hs_RefseqmRNA = NM_006422
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 4594938
    | Hs_GenLoc_end = 4624604
    | Hs_Uniprot = O75969
    | Mm_EntrezGene = 11642
    | Mm_Ensembl = ENSMUSG00000030344
    | Mm_RefseqmRNA = NM_009650
    | Mm_RefseqProtein = NP_033780
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 126825874
    | Mm_GenLoc_end = 126839734
    | Mm_Uniprot = Q497M9
  }}
}}
'''A kinase (PRKA) anchor protein 3''', also known as '''AKAP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10566| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of [[protein kinase A]] (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the [[acrosome]] reaction.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.<ref name="entrez">{{cite web | title = Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10566| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue=  |pages= 409-29; discussion 429-30 |year= 1997 |pmid= 9238861 |doi=  }}
*{{cite journal  | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue=  |pages= 235-57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801 }}
*{{cite journal  | author=Vijayaraghavan S, Liberty GA, Mohan J, ''et al.'' |title=Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. |journal=Mol. Endocrinol. |volume=13 |issue= 5 |pages= 705-17 |year= 1999 |pmid= 10319321 |doi=  }}
*{{cite journal  | author=Lefevre A, Duquenne C, Rousseau-Merck MF, ''et al.'' |title=Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 1 |pages= 60-6 |year= 1999 |pmid= 10334916 |doi= 10.1006/bbrc.1999.0728 }}
*{{cite journal  | author=Mandal A, Naaby-Hansen S, Wolkowicz MJ, ''et al.'' |title=FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. |journal=Biol. Reprod. |volume=61 |issue= 5 |pages= 1184-97 |year= 1999 |pmid= 10529264 |doi=  }}
*{{cite journal  | author=Carr DW, Fujita A, Stentz CL, ''et al.'' |title=Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17332-8 |year= 2001 |pmid= 11278869 |doi= 10.1074/jbc.M011252200 }}
*{{cite journal  | author=Niu J, Vaiskunaite R, Suzuki N, ''et al.'' |title=Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation. |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1686-90 |year= 2002 |pmid= 11696326 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ficarro S, Chertihin O, Westbrook VA, ''et al.'' |title=Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11579-89 |year= 2003 |pmid= 12509440 |doi= 10.1074/jbc.M202325200 }}
*{{cite journal  | author=Brown PR, Miki K, Harper DB, Eddy EM |title=A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. |journal=Biol. Reprod. |volume=68 |issue= 6 |pages= 2241-8 |year= 2004 |pmid= 12606363 |doi= 10.1095/biolreprod.102.013466 }}
*{{cite journal  | author=Hasegawa K, Ono T, Matsushita H, ''et al.'' |title=A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. |journal=Int. J. Cancer |volume=108 |issue= 1 |pages= 86-90 |year= 2003 |pmid= 14618620 |doi= 10.1002/ijc.11565 }}
*{{cite journal  | author=Lea IA, Widgren EE, O'Rand MG |title=Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. |journal=Reprod. Biol. Endocrinol. |volume=2 |issue=  |pages= 57 |year= 2004 |pmid= 15257753 |doi= 10.1186/1477-7827-2-57 }}
*{{cite journal  | author=Sharma S, Qian F, Keitz B, ''et al.'' |title=A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 183-8 |year= 2005 |pmid= 16005946 |doi= 10.1016/j.ygyno.2005.06.006 }}
*{{cite journal  | author=Lefièvre L, Chen Y, Conner SJ, ''et al.'' |title=Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? |journal=Proteomics |volume=7 |issue= 17 |pages= 3066-84 |year= 2007 |pmid= 17683036 |doi= 10.1002/pmic.200700254 }}
}}
{{refend}}


{{protein-stub}}
AKAP3 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[AKAP4]]<ref name = pmid12606363>{{cite journal | vauthors = Brown PR, Miki K, Harper DB, Eddy EM | title = A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum | journal = Biology of Reproduction | volume = 68 | issue = 6 | pages = 2241–8 | date = Jun 2003 | pmid = 12606363 | doi = 10.1095/biolreprod.102.013466 }}</ref>
* [[GNA13]],<ref name = pmid11696326>{{cite journal | vauthors = Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA | title = Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation | journal = Current Biology | volume = 11 | issue = 21 | pages = 1686–90 | date = Oct 2001 | pmid = 11696326 | doi = 10.1016/S0960-9822(01)00530-9 }}</ref> and
* [[PRKAR2A]].<ref name = pmid10319321 /><ref name = pmid11278869>{{cite journal | vauthors = Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S | title = Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 20 | pages = 17332–8 | date = May 2001 | pmid = 11278869 | doi = 10.1074/jbc.M011252200 }}</ref>
 
== References ==
{{Reflist}}
 
==External links==
* {{UCSC gene info|AKAP3}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Lester LB, Scott JD | title = Anchoring and scaffold proteins for kinases and phosphatases | journal = Recent Progress in Hormone Research | volume = 52 | issue =  | pages = 409–29; discussion 429–30 | year = 1997 | pmid = 9238861 | doi =  }}
* {{cite journal | vauthors = Michel JJ, Scott JD | title = AKAP mediated signal transduction | journal = Annual Review of Pharmacology and Toxicology | volume = 42 | issue =  | pages = 235–57 | year = 2002 | pmid = 11807172 | doi = 10.1146/annurev.pharmtox.42.083101.135801 }}
* {{cite journal | vauthors = Mandal A, Naaby-Hansen S, Wolkowicz MJ, Klotz K, Shetty J, Retief JD, Coonrod SA, Kinter M, Sherman N, Cesar F, Flickinger CJ, Herr JC | title = FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa | journal = Biology of Reproduction | volume = 61 | issue = 5 | pages = 1184–97 | date = Nov 1999 | pmid = 10529264 | doi = 10.1095/biolreprod61.5.1184 }}
* {{cite journal | vauthors = Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S | title = Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 20 | pages = 17332–8 | date = May 2001 | pmid = 11278869 | doi = 10.1074/jbc.M011252200 }}
* {{cite journal | vauthors = Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA | title = Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation | journal = Current Biology | volume = 11 | issue = 21 | pages = 1686–90 | date = Oct 2001 | pmid = 11696326 | doi = 10.1016/S0960-9822(01)00530-9 }}
* {{cite journal | vauthors = Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE | title = Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11579–89 | date = Mar 2003 | pmid = 12509440 | doi = 10.1074/jbc.M202325200 }}
* {{cite journal | vauthors = Brown PR, Miki K, Harper DB, Eddy EM | title = A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum | journal = Biology of Reproduction | volume = 68 | issue = 6 | pages = 2241–8 | date = Jun 2003 | pmid = 12606363 | doi = 10.1095/biolreprod.102.013466 }}
* {{cite journal | vauthors = Hasegawa K, Ono T, Matsushita H, Shimono M, Noguchi Y, Mizutani Y, Kodama J, Kudo T, Nakayama E | title = A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis | journal = International Journal of Cancer | volume = 108 | issue = 1 | pages = 86–90 | date = Jan 2004 | pmid = 14618620 | doi = 10.1002/ijc.11565 }}
* {{cite journal | vauthors = Lea IA, Widgren EE, O'Rand MG | title = Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella | journal = Reproductive Biology and Endocrinology | volume = 2 | issue =  | pages = 57 | date = Jul 2004 | pmid = 15257753 | pmc = 484205 | doi = 10.1186/1477-7827-2-57 }}
* {{cite journal | vauthors = Sharma S, Qian F, Keitz B, Driscoll D, Scanlan MJ, Skipper J, Rodabaugh K, Lele S, Old LJ, Odunsi K | title = A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer | journal = Gynecologic Oncology | volume = 99 | issue = 1 | pages = 183–8 | date = Oct 2005 | pmid = 16005946 | doi = 10.1016/j.ygyno.2005.06.006 }}
* {{cite journal | vauthors = Lefièvre L, Chen Y, Conner SJ, Scott JL, Publicover SJ, Ford WC, Barratt CL | title = Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? | journal = Proteomics | volume = 7 | issue = 17 | pages = 3066–84 | date = Sep 2007 | pmid = 17683036 | pmc = 2777308 | doi = 10.1002/pmic.200700254 }}
{{Refend}}
 
[[Category:A-kinase-anchoring proteins]]
 
 
{{Gene-12-stub}}

Latest revision as of 21:54, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.[1][2][3]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.[3]

Interactions

AKAP3 has been shown to interact with:

References

  1. ↑ Lefevre A, Duquenne C, Rousseau-Merck MF, Rogier E, Finaz C (May 1999). "Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition". Biochemical and Biophysical Research Communications. 259 (1): 60–6. doi:10.1006/bbrc.1999.0728. PMID 10334916.
  2. ↑ 2.0 2.1 Vijayaraghavan S, Liberty GA, Mohan J, Winfrey VP, Olson GE, Carr DW (May 1999). "Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein". Molecular Endocrinology. 13 (5): 705–17. doi:10.1210/mend.13.5.0278. PMID 10319321.
  3. ↑ 3.0 3.1 "Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3".
  4. ↑ Brown PR, Miki K, Harper DB, Eddy EM (Jun 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum". Biology of Reproduction. 68 (6): 2241–8. doi:10.1095/biolreprod.102.013466. PMID 12606363.
  5. ↑ Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology. 11 (21): 1686–90. doi:10.1016/S0960-9822(01)00530-9. PMID 11696326.
  6. ↑ Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S (May 2001). "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA". The Journal of Biological Chemistry. 276 (20): 17332–8. doi:10.1074/jbc.M011252200. PMID 11278869.

External links

Further reading


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