AGTRAP: Difference between revisions

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{{Infobox_gene}}
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'''Type-1 angiotensin II receptor-associated protein''' is a [[protein]] that in humans is encoded by the ''AGTRAP'' [[gene]].<ref name="pmid11733189">{{cite journal | vauthors = Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y | title = Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap) | journal = Int J Biochem Cell Biol | volume = 34 | issue = 1 | pages = 93–102 |date=Dec 2001 | pmid = 11733189 | pmc =  | doi =10.1016/S1357-2725(01)00094-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AGTRAP angiotensin II receptor-associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57085| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Angiotensin II receptor-associated protein
| HGNCid = 13539
| Symbol = AGTRAP
| AltSymbols =; ATRAP; MGC29646
| OMIM = 608729
| ECnumber =
| Homologene = 7621
| MGIid = 1339977
| Function =  
  | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57085
    | Hs_Ensembl = ENSG00000177674
    | Hs_RefseqProtein = NP_001035284
    | Hs_RefseqmRNA = NM_001040194
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 11718728
    | Hs_GenLoc_end = 11733413
    | Hs_Uniprot = Q6RW13
    | Mm_EntrezGene = 11610
    | Mm_Ensembl = ENSMUSG00000029007
    | Mm_RefseqmRNA = NM_009642
    | Mm_RefseqProtein = NP_033772
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 146920861
    | Mm_GenLoc_end = 146931803
    | Mm_Uniprot = Q3U7X6
  }}
}}
'''Angiotensin II receptor-associated protein''', also known as '''AGTRAP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AGTRAP angiotensin II receptor-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57085| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: AGTRAP angiotensin II receptor-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57085| accessdate = }}</ref>
| summary_text = This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.<ref name="entrez" />
}}
}}
==Interactions==
AGTRAP has been shown to [[Protein-protein interaction|interact]] with [[GNB2L1]].<ref name=pmid11733189 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AGTRAP}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Daviet L, Lehtonen JY, Tamura K, ''et al.'' |title=Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17058-62 |year= 1999 |pmid= 10358057 |doi=  }}
*{{cite journal  | vauthors=Daviet L, Lehtonen JY, Tamura K |title=Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17058–62 |year= 1999 |pmid= 10358057 |doi=10.1074/jbc.274.24.17058 |display-authors=etal}}
*{{cite journal  | author=Cui T, Nakagami H, Iwai M, ''et al.'' |title=ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 938-41 |year= 2001 |pmid= 11162453 |doi= 10.1006/bbrc.2000.4055 }}
*{{cite journal  | vauthors=Cui T, Nakagami H, Iwai M |title=ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 938–41 |year= 2001 |pmid= 11162453 |doi= 10.1006/bbrc.2000.4055 |display-authors=etal}}
*{{cite journal  | author=Wang W, Huang Y, Zhou Z, ''et al.'' |title=Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap). |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 1 |pages= 93-102 |year= 2002 |pmid= 11733189 |doi= }}
*{{cite journal  | vauthors=Wistow G, Bernstein SL, Wyatt MK |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants |journal=Mol. Vis. |volume=8 |issue=  |pages= 171–84 |year= 2002 |pmid= 12107413 |doi=  |display-authors=etal}}
*{{cite journal  | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 171-84 |year= 2002 |pmid= 12107413 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ |title=The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 5038–50 |year= 2004 |pmid= 12960423 |doi= 10.1091/mbc.E03-06-0383 | pmc=284805 }}
*{{cite journal  | author=Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ |title=The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 5038-50 |year= 2004 |pmid= 12960423 |doi= 10.1091/mbc.E03-06-0383 }}
*{{cite journal  | vauthors=Guo DF, Chenier I, Tardif V |title=Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1254–65 |year= 2003 |pmid= 14559250 |doi=10.1016/j.bbrc.2003.09.154 |display-authors=etal}}
*{{cite journal  | author=Guo DF, Chenier I, Tardif V, ''et al.'' |title=Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1254-65 |year= 2003 |pmid= 14559250 |doi=  }}
*{{cite journal  | vauthors=Guo DF, Tardif V, Ghelima K |title=A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21109–20 |year= 2004 |pmid= 14985364 |doi= 10.1074/jbc.M401544200 |display-authors=etal}}
*{{cite journal  | author=Guo DF, Tardif V, Ghelima K, ''et al.'' |title=A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21109-20 |year= 2004 |pmid= 14985364 |doi= 10.1074/jbc.M401544200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Guo S, Lopez-Ilasaca M, Dzau VJ |title=Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12536–41 |year= 2005 |pmid= 15668245 |doi= 10.1074/jbc.M500296200 }}
*{{cite journal  | author=Guo S, Lopez-Ilasaca M, Dzau VJ |title=Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12536-41 |year= 2005 |pmid= 15668245 |doi= 10.1074/jbc.M500296200 }}
*{{cite journal  | vauthors=Tanaka Y, Tamura K, Koide Y |title=The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1579–86 |year= 2005 |pmid= 15757644 |doi= 10.1016/j.febslet.2005.01.068 |display-authors=etal}}
*{{cite journal  | author=Tanaka Y, Tamura K, Koide Y, ''et al.'' |title=The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy. |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1579-86 |year= 2005 |pmid= 15757644 |doi= 10.1016/j.febslet.2005.01.068 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 17:53, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.[1][2]

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[2]

Interactions

AGTRAP has been shown to interact with GNB2L1.[1]

References

  1. ↑ 1.0 1.1 Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
  2. ↑ 2.0 2.1 "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

External links

Further reading



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