ADAM9

ADAM metallopeptidase domain 9 (meltrin gamma)
Identifiers
Symbols	ADAM9 ; MCMP; KIAA0021; MDC9; Mltng
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20824
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ADAM metallopeptidase domain 9 (meltrin gamma), also known as ADAM9, is a human gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.

Further reading

• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. PMID 7584026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. PMID 7584028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weskamp G, Krätzschmar J, Reid MS, Blobel CP (1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains". J. Cell Biol. 132 (4): 717–26. PMID 8647900.CS1 maint: Multiple names: authors list (link)
• McKie N, Dallas DJ, Edwards T; et al. (1996). "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells". Biochem. J. 318 ( Pt 2): 459–62. PMID 8809033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McKie N, Edwards T, Dallas DJ; et al. (1997). "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes". Biochem. Biophys. Res. Commun. 230 (2): 335–9. doi:10.1006/bbrc.1996.5957. PMID 9016778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izumi Y, Hirata M, Hasuwa H; et al. (1999). "A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor". EMBO J. 17 (24): 7260–72. doi:10.1093/emboj/17.24.7260. PMID 9857183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roghani M, Becherer JD, Moss ML; et al. (1999). "Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity". J. Biol. Chem. 274 (6): 3531–40. PMID 9920899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nelson KK, Schlöndorff J, Blobel CP (2000). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 Pt 3: 673–80. PMID 10527948.CS1 maint: Multiple names: authors list (link)
• Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. PMID 10531379.CS1 maint: Multiple names: authors list (link)
• Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.CS1 maint: Multiple names: authors list (link)
• Namba K, Nishio M, Mori K; et al. (2002). "Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes". Cell. Immunol. 213 (2): 104–13. doi:10.1006/cimm.2001.1873. PMID 11831872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eto K, Huet C, Tarui T; et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". J. Biol. Chem. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim JM, Lee JH, Wee WR, Joo CK (2002). "Downregulated expression of ADAM9 in anterior polar cataracts". Journal of cataract and refractive surgery. 28 (4): 697–702. PMID 11955914.CS1 maint: Multiple names: authors list (link)
• Hotoda N, Koike H, Sasagawa N, Ishiura S (2002). "A secreted form of human ADAM9 has an alpha-secretase activity for APP". Biochem. Biophys. Res. Commun. 293 (2): 800–5. doi:10.1016/S0006-291X(02)00302-9. PMID 12054541.CS1 maint: Multiple names: authors list (link)
• Amour A, Knight CG, English WR; et al. (2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Lett. 524 (1–3): 154–8. PMID 12135759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mohan S, Thompson GR, Amaar YG; et al. (2003). "ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts". Biochemistry. 41 (51): 15394–403. PMID 12484779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asai M, Hattori C, Szabó B; et al. (2003). "Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase". Biochem. Biophys. Res. Commun. 301 (1): 231–5. PMID 12535668.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Shea C, McKie N, Buggy Y; et al. (2003). "Expression of ADAM-9 mRNA and protein in human breast cancer". Int. J. Cancer. 105 (6): 754–61. doi:10.1002/ijc.11161. PMID 12767059.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grützmann R, Lüttges J, Sipos B; et al. (2004). "ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma". Br. J. Cancer. 90 (5): 1053–8. doi:10.1038/sj.bjc.6601645. PMID 14997207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)