ADAM22

ADAM metallopeptidase domain 22
Identifiers
Symbols	ADAM22 ; MDC2; MGC149832
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37898
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ADAM metallopeptidase domain 22, also known as ADAM22, is a human gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.

Further reading

• Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". Biochem. J. 334 ( Pt 1): 93–8. PMID 9693107.CS1 maint: Multiple names: authors list (link)
• Poindexter K, Nelson N, DuBose RF; et al. (1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. PMID 10524237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada T, Nishie A, Torigoe K; et al. (2001). "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas". Jpn. J. Cancer Res. 91 (10): 1001–6. PMID 11050470.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu P, Sun Y, Xu R; et al. (2003). "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading". Biochem. Biophys. Res. Commun. 301 (4): 991–9. PMID 12589811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.CS1 maint: Multiple names: authors list (link)
• Sagane K, Hayakawa K, Kai J; et al. (2006). "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice". BMC neuroscience. 6 (1): 33. doi:10.1186/1471-2202-6-33. PMID 15876356.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu P, Sang Y, Xu H; et al. (2005). "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3". Biochem. Biophys. Res. Commun. 331 (4): 938–46. doi:10.1016/j.bbrc.2005.03.229. PMID 15882968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• D'Abaco GM, Ng K, Paradiso L; et al. (2006). "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain". Neurosurgery. 58 (1): 179–86, discussion 179-86. PMID 16385342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gödde NJ, D'Abaco GM, Paradiso L, Novak U (2006). "Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members". J. Cell. Sci. 119 (Pt 16): 3296–305. doi:10.1242/jcs.03065. PMID 16868027.CS1 maint: Multiple names: authors list (link)
• Fukata Y, Adesnik H, Iwanaga T; et al. (2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. doi:10.1126/science.1129947. PMID 16990550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chabrol E, Gourfinkel-An I, Scheffer IE; et al. (2007). "Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy". Epilepsy Res. 76 (1): 41–8. doi:10.1016/j.eplepsyres.2007.06.014. PMID 17681454.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gödde NJ, D'Abaco GM, Paradiso L, Novak U (2007). "Differential coding potential of ADAM22 mRNAs". Gene. 403 (1–2): 80–8. doi:10.1016/j.gene.2007.07.033. PMID 17884303.CS1 maint: Multiple names: authors list (link)