ABCG4: Difference between revisions

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{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''ATP-binding cassette sub-family G member 4''' is a [[protein]] that in humans is encoded by the ''ABCG4'' [[gene]].<ref name="pmid11435397">{{cite journal | vauthors = Dean M, Rzhetsky A, Allikmets R | title = The human ATP-binding cassette (ABC) transporter superfamily | journal = Genome Res | volume = 11 | issue = 7 | pages = 1156–66 |date=Jul 2001 | pmid = 11435397 | pmc =  | doi = 10.1101/gr.184901 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64137| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ATP-binding cassette, sub-family G (WHITE), member 4
| HGNCid = 13884
| Symbol = ABCG4
| AltSymbols =; WHITE2
| OMIM = 607784
| ECnumber = 
| Homologene = 75179
| MGIid = 1890594
| GeneAtlas_image1 = PBB_GE_ABCG4_207593_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006810 |text = transport}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64137
    | Hs_Ensembl = ENSG00000172350
    | Hs_RefseqProtein = NP_071452
    | Hs_RefseqmRNA = NM_022169
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 118524960
    | Hs_GenLoc_end = 118538582
    | Hs_Uniprot = Q9H172
    | Mm_EntrezGene = 192663
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_989152
    | Mm_RefseqProtein = XP_994246
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr =
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
{{CMG}}
__NOTOC__
 
 
==Overview==


'''ATP-binding cassette, sub-family G (WHITE), member 4''', also known as '''ABCG4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64137| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64137| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is included in the [[ATP-binding cassette transporter]] (ABC protein) superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.<ref name="entrez"/>
}}
}}
==See also==
==See also==
* [[ATP-binding cassette transporter]]
* [[ATP-binding cassette transporter]]
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dean M, Rzhetsky A, Allikmets R |title=The human ATP-binding cassette (ABC) transporter superfamily. |journal=Genome Res. |volume=11 |issue= 7 |pages= 1156-66 |year= 2001 |pmid= 11435397 |doi= 10.1101/gr.184901 }}
*{{cite journal  | vauthors=Engel T, Lorkowski S, Lueken A |title=The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 2 |pages= 483–8 |year= 2001 |pmid= 11606068 |doi= 10.1006/bbrc.2001.5756 |display-authors=etal}}
*{{cite journal  | author=Engel T, Lorkowski S, Lueken A, ''et al.'' |title=The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 2 |pages= 483-8 |year= 2001 |pmid= 11606068 |doi= 10.1006/bbrc.2001.5756 }}
*{{cite journal  | vauthors=Annilo T, Tammur J, Hutchinson A |title=Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 3-4 |pages= 196–201 |year= 2002 |pmid= 11856881 |doi=10.1159/000048816 |display-authors=etal}}
*{{cite journal  | author=Annilo T, Tammur J, Hutchinson A, ''et al.'' |title=Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 3-4 |pages= 196-201 |year= 2002 |pmid= 11856881 |doi=  }}
*{{cite journal  | vauthors=Yoshikawa M, Yabuuchi H, Kuroiwa A |title=Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. |journal=Gene |volume=293 |issue= 1-2 |pages= 67–75 |year= 2002 |pmid= 12137944 |doi=10.1016/S0378-1119(02)00719-9 |display-authors=etal}}
*{{cite journal  | author=Yoshikawa M, Yabuuchi H, Kuroiwa A, ''et al.'' |title=Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. |journal=Gene |volume=293 |issue= 1-2 |pages= 67-75 |year= 2002 |pmid= 12137944 |doi=  }}
*{{cite journal  | vauthors=Oldfield S, Lowry C, Ruddick J, Lightman S |title=ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 175–9 |year= 2002 |pmid= 12183068 |doi=10.1016/S0167-4889(02)00269-0 }}
*{{cite journal  | author=Oldfield S, Lowry C, Ruddick J, Lightman S |title=ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 175-9 |year= 2002 |pmid= 12183068 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Cserepes J, Szentpétery Z, Seres L |title=Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 3 |pages= 860–7 |year= 2004 |pmid= 15240127 |doi= 10.1016/j.bbrc.2004.06.037 |display-authors=etal}}
*{{cite journal  | author=Cserepes J, Szentpétery Z, Seres L, ''et al.'' |title=Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 3 |pages= 860-7 |year= 2004 |pmid= 15240127 |doi= 10.1016/j.bbrc.2004.06.037 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Engel T, Bode G, Lueken A |title=Expression and functional characterization of ABCG1 splice variant ABCG1(666). |journal=FEBS Lett. |volume=580 |issue= 18 |pages= 4551–9 |year= 2006 |pmid= 16870176 |doi= 10.1016/j.febslet.2006.07.006 |display-authors=etal}}
*{{cite journal  | author=Engel T, Bode G, Lueken A, ''et al.'' |title=Expression and functional characterization of ABCG1 splice variant ABCG1(666). |journal=FEBS Lett. |volume=580 |issue= 18 |pages= 4551-9 |year= 2006 |pmid= 16870176 |doi= 10.1016/j.febslet.2006.07.006 }}
*{{cite journal  | vauthors=Vaughan AM, Oram JF |title=ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. |journal=J. Lipid Res. |volume=47 |issue= 11 |pages= 2433–43 |year= 2007 |pmid= 16902247 |doi= 10.1194/jlr.M600218-JLR200 }}
*{{cite journal  | author=Vaughan AM, Oram JF |title=ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. |journal=J. Lipid Res. |volume=47 |issue= 11 |pages= 2433-43 |year= 2007 |pmid= 16902247 |doi= 10.1194/jlr.M600218-JLR200 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|ABCG4+protein,+human}}
* {{MeshName|ABCG4+protein,+human}}
* {{UCSC gene info|ABCG4}}


{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{ABC transporters}}
 
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{{DEFAULTSORT:Abcg4}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]




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Latest revision as of 17:40, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-binding cassette sub-family G member 4 is a protein that in humans is encoded by the ABCG4 gene.[1][2]

The protein encoded by this gene is included in the ATP-binding cassette transporter (ABC protein) superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.[2]

See also

References

  1. ↑ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397.
  2. ↑ 2.0 2.1 "Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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