ABCA8: Difference between revisions

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{{Infobox_gene}}
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'''ATP-binding cassette sub-family A member 8''' is a [[protein]] that in [[human]]s is encoded by the ''ABCA8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10351| accessdate = }}</ref>
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| update_protein_box = yes
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ATP-binding cassette, sub-family A (ABC1), member 8
| HGNCid = 38
| Symbol = ABCA8
| AltSymbols =; KIAA0822; MGC163152
| OMIM = 
| ECnumber = 
| Homologene = 56029
| MGIid = 1351668
| GeneAtlas_image1 = PBB_GE_ABCA8_204719_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}}{{GNF_GO|id=GO:0005524 |text = ATP binding}}{{GNF_GO|id=GO:0016887 |text = ATPase activity}}{{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10351
    | Hs_Ensembl = ENSG00000141338
    | Hs_RefseqProtein = NP_009099
    | Hs_RefseqmRNA = NM_007168
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 64375028
    | Hs_GenLoc_end = 64463128
    | Hs_Uniprot = O94911
    | Mm_EntrezGene = 27404
    | Mm_Ensembl = ENSMUSG00000020620
    | Mm_RefseqmRNA = NM_013851
    | Mm_RefseqProtein = NP_038879
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 109750357
    | Mm_GenLoc_end = 109811906
    | Mm_Uniprot = Q8K440
  }}
}}
{{CMG}}
__NOTOC__
 
 
==Overview==
 
'''ATP-binding cassette, sub-family A (ABC1), member 8''', also known as '''ABCA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10351| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10351| accessdate = }}</ref>
| summary_text = The [[membrane]]-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across [[extracellular|extra]]- and [[intracellular]] membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in [[multicellular]] [[eukaryotes]]. The function of this protein has not yet been determined.<ref name="entrez"/>
}}
}}
==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{Cite journal | author = Mammalian Gene Collection Program Team | display-authors = 4 | last2 = Strausberg | first2 = R. L. | last3 = Feingold | first3 = E. A. | last4 = Grouse | first4 = L. H. | last5 = Derge | first5 = J. G. | last6 = Klausner | first6 = R. D. | last7 = Collins | first7 = F. S. | last8 = Wagner | first8 = L. | last9 = Shenmen | first9 = C. M. | last10 = Schuler | first10 = G. D. | doi = 10.1073/pnas.242603899 | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = [[Proceedings of the National Academy of Sciences of the United States of America|Proceedings of the National Academy of Sciences]] | volume = 99 | issue = 26 | pages = 16899–16903 | pmc = 139241 | year = 2002 | pmid = 12477932}}
*{{cite journal  | author=Tsuruoka S, Ishibashi K, Yamamoto H, ''et al.'' |title=Functional analysis of ABCA8, a new drug transporter. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 1 |pages= 41-5 |year= 2002 |pmid= 12379217 |doi=  }}
*{{cite journal  |vauthors=Tsuruoka S, Ishibashi K, Yamamoto H |title=Functional analysis of ABCA8, a new drug transporter. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 1 |pages= 41–5 |year= 2002 |pmid= 12379217 |doi=10.1016/S0006-291X(02)02389-6 |display-authors=etal}}
*{{cite journal  | author=Iida A, Saito S, Sekine A, ''et al.'' |title=Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. |journal=J. Hum. Genet. |volume=47 |issue= 6 |pages= 285-310 |year= 2002 |pmid= 12111378 |doi= 10.1007/s100380200041 }}
*{{cite journal  |vauthors=Iida A, Saito S, Sekine A |title=Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. |journal=J. Hum. Genet. |volume=47 |issue= 6 |pages= 285–310 |year= 2002 |pmid= 12111378 |doi= 10.1007/s100380200041 |display-authors=etal}}
*{{cite journal  | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal  |vauthors=Harrington JJ, Sherf B, Rundlett S |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
*{{cite journal  |vauthors=Nagase T, Ishikawa K, Suyama M |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=10.1093/dnares/5.6.355 |display-authors=etal}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
}}
}}
{{refend}}
{{refend}}


{{Membrane transport proteins}}
== External links ==
* {{UCSC genome browser|ABCA8}}  
* {{UCSC gene details|ABCA8}}
 
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{{ABC transporters}}
 
{{DEFAULTSORT:Abca8}}
 


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Latest revision as of 17:38, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene.[1]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8".

Further reading

External links




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