8-Hydroxyquinoline

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8-Hydroxyquinoline, or oxyquinoline, is an organic compound with the formula C9H7NO, a derivative of quinoline. It is usually extracted from coal tar.[1] This white compound is widely used as a chelating agent, where it binds to metals as a bidentate ligand. It is widely used commercially, although under a variety of names.[2][3]

It is used as a metal chelator, antiseptic, disinfectant and pesticide.[4][5] Its solution in alcohol are used as liquid bandages. It once was of interest as an anti-cancer drug.[6]

The roots of the invasive plant Centaurea diffusa release the 8-hydroxyquinoline, which has a negative effect on plants that have not co-evolved with it.

Safety

See MSDS.[2]

References

  1. American Chemical Society
  2. 2.0 2.1 Oxford University 8-hydroxyquinoline Safety Data
  3. Pesticide Database
  4. Phillips, J. P. “The Reactions Of 8-Quinolinol” Chemical Reviews 1956, volume 56, pp 271 - 297; DOI: 10.1021/cr50008a003
  5. Medical Dictionary Online
  6. Shen AY, Wu SN, Chiu CT (1999). "Synthesis and cytotoxicity evaluation of some 8-hydroxyquinoline derivatives". J. Pharm. Pharmacol. 51 (5): 543–8. PMID 10411213.


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