2C-T-8
| 2C-T-8 | |
|---|---|
| Chemical name | (2-{4-[(cyclopropylmethyl)thio]-2,5-dimethoxyphenyl}ethanamine |
| Chemical formula | C14H21NO2S |
| Molecular mass | 267.387 g/mol |
| Melting point | ? |
| CAS numbers | 207740-27-0 |
| SMILES | COc2cc(SCC1CC1)c(cc2CCN)OC |
| Chemical structure of 2C-T-8 File:2C-T-8-3d-sticks.png | |
2C-T-8 is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin, sometimes used as an entheogen.
Chemistry
The full name of the chemical is 2,5-dimethoxy-4-cyclopropylmethylthiophenethylamine. The compound is reported to have a bad taste and smell.
Effects
In his book PIHKAL (Phenethylamines I Have Known and Loved), Shulgin lists the dosage range as 30 to 50 mg. 2C-T-8 is generally taken orally, and effects typically last 10 to 15 hours. Experiences have varied between insight and creativity at low doses to hypersensitivity and paranoia at higher doses. A "thinking-connection" that is characteristic of the 2C-T group is evident in this chemical in stark contrast to the "pure euphoria" of phenethylamines such as MDMA.[1]
Legality
2C-T-8 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-8 will probably be prosecuted under the Federal Analog Act because of its structural similarities to 2C-T-7. However, 2C-T-8, unlike many other phenethylamines has not been sold by internet retailers. In the wake of Operation Web Tryp in July 2004, the issue of possession and sales of 2C-T-8 and other similar chemicals will probably be resolved in the courtroom as will the fate of this rare but unique psychedelic. There have been no reported deaths from 2C-T-8.
Pharmacology
The mechanism that produces 2C-T-8’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
Dangers
The toxicity of 2C-T-8 is not well documented. 2C-T-8 is somewhat less potent than 2C-T-7, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as 2C-T-7 and 4-MTA are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome when they are combined with stimulant drugs.
There have been no confirmed deaths due to 2C-T-8[citation needed], though this may in part be due to its rarity and limited usage. Of the 2C-T family, there have been a few confirmed deaths due to 2C-T-7, which involved either insufflating large (30mg+) doses[1][2] and in one case an unknown oral dose was combined with 200mg MDMA[3].
Popularity
2C-T-8 is unknown on the black market. Limited accounts of 2C-T-8 can be found in the book PiHKAL.