2-Oxazolidone

Jump to navigation Jump to search

Template:Chembox new

WikiDoc Resources for 2-Oxazolidone

Articles

Most recent articles on 2-Oxazolidone

Most cited articles on 2-Oxazolidone

Review articles on 2-Oxazolidone

Articles on 2-Oxazolidone in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on 2-Oxazolidone

Images of 2-Oxazolidone

Photos of 2-Oxazolidone

Podcasts & MP3s on 2-Oxazolidone

Videos on 2-Oxazolidone

Evidence Based Medicine

Cochrane Collaboration on 2-Oxazolidone

Bandolier on 2-Oxazolidone

TRIP on 2-Oxazolidone

Clinical Trials

Ongoing Trials on 2-Oxazolidone at Clinical Trials.gov

Trial results on 2-Oxazolidone

Clinical Trials on 2-Oxazolidone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on 2-Oxazolidone

NICE Guidance on 2-Oxazolidone

NHS PRODIGY Guidance

FDA on 2-Oxazolidone

CDC on 2-Oxazolidone

Books

Books on 2-Oxazolidone

News

2-Oxazolidone in the news

Be alerted to news on 2-Oxazolidone

News trends on 2-Oxazolidone

Commentary

Blogs on 2-Oxazolidone

Definitions

Definitions of 2-Oxazolidone

Patient Resources / Community

Patient resources on 2-Oxazolidone

Discussion groups on 2-Oxazolidone

Patient Handouts on 2-Oxazolidone

Directions to Hospitals Treating 2-Oxazolidone

Risk calculators and risk factors for 2-Oxazolidone

Healthcare Provider Resources

Symptoms of 2-Oxazolidone

Causes & Risk Factors for 2-Oxazolidone

Diagnostic studies for 2-Oxazolidone

Treatment of 2-Oxazolidone

Continuing Medical Education (CME)

CME Programs on 2-Oxazolidone

International

2-Oxazolidone en Espanol

2-Oxazolidone en Francais

Business

2-Oxazolidone in the Marketplace

Patents on 2-Oxazolidone

Experimental / Informatics

List of terms related to 2-Oxazolidone


2-Oxazolidone is a heterocyclic organic compound containing both nitrogen and oxygen in a 5-membered ring.

Oxazolidinones

Evans auxiliaries

Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. In chemistry, they are useful as Evans auxiliaries, which are used for chiral synthesis. Usually, the acid chloride substrate reacts with the oxazolidinone to form an imide. Substituents at the 4 and 5 position of the oxazolidinone direct any aldol reaction to the alpha position of the carbonyl of the substrate.

Pharmaceuticals

Oxazolidinones are used as antibiotics. Some of the most important oxazolidinones are the last generation of antibiotics used against gram-positive pathogens, including superbugs such as Methicillin-resistant Staphylococcus aureus. Developed during the nineties when several bacterial strains were becoming resistant against such antibiotics as vancomycin. These antibiotics are considered as a choice of last resort where every other antibiotic therapy has failed. Linezolid (Zyvox), the only currently available agent in this class, is available for intravenous administration and also has the advantage of having excellent oral bioavailability.

Chemical structure of AZD2563

The first commercially available oxazolidinone antibiotic was Linezolid. In 2002 AstraZeneca introduced the AZD2563 antibiotic. Results indicate that AZD2563 has excellent, targeted activity against all common gram-positive bacteria, regardless of resistance to other classes of antibiotics. The anticoagulant rivaroxaban, an oxazolidinone derivative, is undergoing trials.

References


External links


de:Oxazolidinone


Template:WikiDoc Sources