]> 2026-07-31T14:08:23+00:00 WBR230 0 en Deposition of an immunoglobulin subclass deficient in galactose IgA nephropathy (Berger’s disease) is the most common primary glomerulonephritis worldwide. It is characterized by deposition of IgA in the glomerular mesangium leading to mesangial proliferation. The IgA1 is almost always the subclass involved and contains O-glycans deficient in galactose. Circulating immune complexes triggering the activation of complement pathways Selective loss of albumin caused by basement membrane polyanion loss Deposition of protein sheets that stain positive for Congo Red Generation of advanced glycosylation end products and acceleration of aldose reductase pathway Pathology A 21-year-old man presents to the urgent care clinic for dark colored urine. Upon further questioning, the patient reports he has recently recovered from a flu-like illness 4 days prior to presentation. Patient denies dysuria, frequency, or urgency. Patient’s vital signs reveal a temperature of 36.7 degree C (98 degree F), heart rate of 68 beats per minute, and blood pressure measuring 110/85 mmHg. Patient’s physical examination is unremarkable. After appropriate work-up, renal biopsy reveals mesangial proliferation. Which finding is most consistent with the pathogenesis of the patient’s condition? A Renal 2020-10-28T02:48:24Z 2459150.6169444 WBR230