]> 2026-07-31T11:51:14+00:00 WBR1141 0 en Prostate cancer Osteopetrosis Osteomalacia Pagets disease Hyperthyroidism Post thyroidectomy every patient receives thyroxine supplement. Obtimal doses of thyroxine is adjusted by regular monitoring of TSH. The patient is suffering from difficulty concentrating, fatigue, frequent bowel movements, heat intolerance, increased appetite, increased sweating, nervousness, restlessness and insomnia, from last 8 months. Which is indicative of excess thyroxine dose. Thyroxine activates osteoclasts, which results in osteoporosis. Vertebral fracture is one of the most common manifestation of osteoporosis. Thyroxine activates osteoclasts, which results in osteoporosis. Vertebral fracture is one of the most common manifestation of osteoporosis.<br/> '''Educational Objective:''' <br/> '''References:''' http://www.wikidoc.org/index.php/Hyperthyroidism_pathophysiology http://www.ncbi.nlm.nih.gov/pubmed/24570805 Internal medicine 41 year old man is diagnosed with a new vertebral fracture. He also complains of difficulty concentrating, fatigue, frequent bowel movements, heat intolerance, increased appetite, increased sweating, nervousness, restlessness and insomnia, from last 8 months. Ten years back, he underwent subtotal thyroidectomy, as he was suffering from graves disease. He denies family history of prostate cancer, osteomalacia and osteopetrosis. What is the most likely cause of vertebral fracture? E Endocrine 2020-10-28T02:44:12Z 2459150.6140278 WBR1141