]> 2026-07-31T16:29:17+00:00 WBR1092 0 en Valproic acid Valproate causes birth defects; exposure during pregnancy is associated with about three times as many major anomalies as usual, mainly spina bifida and, more rarely, with several other defects, possibly including a "valproate syndrome".Characteristics of this valproate syndrome include facial features that tend to evolve with age, including trigonocephaly, tall forehead with bifrontal narrowing, epicanthic folds, medial deficiency of eyebrows, flat nasal bridge, broad nasal root, anteverted nares, shallow philtrum, long upper lip and thin vermillion borders, thick lower lip and small downturned mouth. Valproate can cause neural tube defects Alcohol LSD Marijuana Cannabis consumption in pregnancy is associated with restrictions in growth of the fetus, miscarriage, and cognitive deficits in offspring Aspirin Aspirin (NSAIDs) are not recommended during pregnancy, particularly during the third trimester. While NSAIDs as a class are not direct teratogens, they may cause premature closure of the fetal ductus arteriosus and renal ADRs in the fetus. Additionally, they are linked with premature birth and miscarriage. Pharmacology Pediatrics Chetan Lokhande A 12-month old female child is brought to the office for a routine examination. On enquiry the mother states that the baby was born prematurely and her weight was 4.4. Lbs. On examination of the child you notice that the child cannot sit unsupported. On examination of the head a smaller than usual head is noticed. Examination of the face reveals a smooth philtrum, thin vermillion and small palpebral fissures. What could be the most likely cause of these facial features? B Pulmonology Pediatrics Poisoning Preventive Medicine 2020-10-28T02:35:42Z 2459150.608125 WBR1092