]> 2026-07-31T09:41:35+00:00 WBR0978 0 en Aldose reductase Sorbitol dehydrogenase While glucose is normally converted to sorbitol by the action of aldose reductase and then to fructose by the action of sorbitol dehydrogenase, some cells lack sorbitol dehydrogenase expression (cells of the retina, Schwann cells, and the kidneys) and are predisposed to osmotic damage when exposed to chronically high concentrations of sorbitol. Aldolase B Triose kinase NADPH oxidase Biochemistry A 73-year-old woman presents with worsening pain in her left foot. Her past medical history is remarkable for a 20-year history of poorly type 2 controlled diabetes mellitus. Her temperature is 38.3 °C (100.9 °F), heart rate is 98/min, and blood pressure is 146/90 mmHg. On physical examination, the left foot is warm, erythematous, and tender, and an ulcer that involves the full thickness of the skin present. The right lower extremity appears normal. The patient is informed that her condition is a complication of her poorly controlled diabetes. Deficiency of which of the following enzymes in nerve cells is responsible for the organ damage associated with this patient's condition? B Neurology 2020-10-28T02:15:54Z 2459150.594375 WBR0978