]> 2026-07-31T11:51:09+00:00 WBR0949 0 en Decrease in altitude A decrease in altitude would left-shift the oxygen-hemoglobin dissociation curve. Decrease in temperature A decrease in temperature would left-shift the oxygen-hemoglobin dissociation curve. Decrease in CO2 A decrease in CO2 would left-shift the oxygen-hemoglobin dissociation curve. Increase in 2,3-bisphosphoglycerate (2,3-BPG) An increase in 2,3-BPG would right-shift the oxygen-hemoglobin dissociation curve. Increase in carbon monoxide (CO) Because carbon monoxide (CO) has a 200x higher affinity for hemoglobin than does oxygen, an increase in CO would cause a non-competitive decrease in the oxygen binding capacity of hemoglobin. This patient has a high anion gap metabolic acidosis due to salicylate toxicity. The criteria for high anion gap metabolic acidosis is pH < 7.35 and an anion gap >16 (anion gap limit differs with age). The anion gap is defined by the following equation: Anion Gap = Na - Cl - Bicarbonate In this case, the anion gap equals 140-100-15= 25. The oxygen-hemoglobin dissociation curve is right shifted by a decrease in pH (increasing acidity). The following factors result in a right shift of the oxygen-hemoglobin dissociation curve: *CO2 *BPG (2,3-BPG) *Exercise *Acidic pH *High altitude *High temperature '''Educational Objective:''' The following factors result in a right shift of the oxygen-hemoglobin dissociation curve: *CO2 *BPG (2,3-BPG) *Exercise *Acidic pH *High altitude *High temperature '''References:''' First Aid 2013 page 548 Biochemistry Physiology A 22-year-old woman is brought to the emergency department (ED) after several members of her family witnessed her suffering a seizure. On the way to the hospital, she admitted to swallowing 50 aspirin pills in a suicide attempt. She is unconscious but responds to painful stimuli. In the ED, results from arterial blood gas on room air demonstrate the following: pH=7.32, pCO2=18 mmHg, pO2=111 mmHg, Bicarbonate=15 mEq/L. Blood samples are withdrawn, and electrolytes are as follows: Sodium=140 mEq/L, Chloride=100 mEq/L. Which of the following would have a similar effect on the oxygen-hemoglobin dissociation curve as this patient’s condition? D Pulmonology 2020-10-28T02:09:40Z

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