]> 2026-07-31T11:51:13+00:00 WBR0946 0 en Methimazole Methimazole is an anti-thyroid drug that inhibits thyroperoxidase, an enzyme essential for the synthesis of T4. Because De Quervain’s thyroiditis eventually causes hypothyroidism, an anti-thyroid drug is not recommended. Propylthiouracil Propylthiouracil (PTU) is an anti-thyroid drug that inhibits thyroperoxidase, an enzyme essential for the synthesis of T4. It also inhibits the conversion of T4 to T3 peripherally. Because De Quervain’s thyroiditis eventually causes hypothyroidism, an anti-thyroid drug is not recommended. Surgery De Quervain’s thyroiditis usually self-resolves, and surgery is not recommended. Aspirin Patients with De Quervain’s thyroiditis should be treated with NSAIDs to decrease inflammation and a beta-blocker to manage the symptoms of hyperthyroidism in the acute phase. Levothyroxine At this stage, the patient is displaying symptoms of hyperthyroidism. Eventually, patients with De Quervain’s thyroiditis return to a euthyroid state. Pharmacology A 36-year-old man presents to his primary care physician for anxiety, palpitations, and insomnia over the past week. The patient also reports dysphagia and unintentional weight loss. Physical examination is remarkable for a heart rate of 110/min and a tender neck mass. Radionuclide thyroid scan is abnormal and reveals a deceased uptake. Which of the following is the most appropriate therapy to manage this patient's condition? D Endocrine 2020-10-28T02:09:10Z 2459150.5896991 WBR0946