]> 2026-07-31T11:51:06+00:00 WBR0750 0 en Endomysial inflammation Endomysial inflammation is characteristic of polymyositis. Perimysial inflammation Perimysial inflammation is characteristic of dermatomyositis. Non-caseating granulomas Non-caseating granulomas are commonly observed in sarcoidosis. Precipitation of monosodium urate crystals Precipitation of monosodium urate crystals is characteristic of gout. Autoimmune inflammatory destruction of synovial joints Rheumatoid arthritis (RA) is characterized by the autoimmune inflammatory destruction of synovial joints. Dermatomyositis is an inflammatory myopathy characterized by symmetric proximal and truncal weakness with or without associated pain. Physical examination is typically remarkable for Gottron papules (violaceous flat-topped papules and plaques in the dorsal aspect of the hand) and characteristic heliotrope rash (periorbital violaceous erythema with periorbital edema). Work-up often demonstrates elevation of muscle biomarkers, such as creatine kinase. Pathologically, dermatomyositis is considered a perimysial inflammation with lymphocytic infiltration that is generally confined to the septa. Dermatomyositis has a bi-modal peak incidence. In adult patients > 50 years of age, the diagnosis of dermatomyositis prompts the investigation of a malignancy due to frequent association. This is not true, however, for those diagnosed at young age.<br/> '''Educational Objective:''' Dermatomyositis is characterized by perimysial inflammation.<br/> '''References:''' Khan S, Christopher-Stine L. Polymyositis, dermatomyositis, and autoimmune necrotizing myopathy: clinical features. Rheum Dis Clin N Am. 2011; 37:143-158.<br Dalakas M. Polymyositis, dermatomyositis, and inclusion-body myositis. N Engl J Med. 1991; 325:1487-1498.<br> First Aid 2014 page 429. Pathology A 62-year-old woman presents to the physician's office with complaints of of muscle weakness for the past 3 weeks. She states that she has recently been unable to comb her hair or stand from a seated position. When asked, she says that she has no difficulty buttoning shirts. Review of systems is remarkable for arthralgia that involves the hand joints, wrists, and knees. Inspection of the patient's face shows periorbital violaceous erythema with edematous eyelids. Physical examination is remarkable for symmetric proximal muscle weakness. Further evaluation of her dorsal interphalangeal and metacarpophalangeal joints reveals violaceous flat-topped papules and plaques. Lab work-up is remarkable for elevated concentration of creatine kinase. What is the histopathological feature of this patient's condition? B Musculoskeletal/Rheumatology 2020-10-28T01:34:42Z 2459150.5657639 WBR0750