]> 2026-07-31T09:41:43+00:00 WBR0710 0 en Progressive multifocal leukoencephalopathy Correct Classic MRI findings of PML consist of multiple demyelinating, non enhancing lesions with no mass effect. Toxoplasmosis Incorrect Toxoplasmosis are common with AIDS, but associated with ring-enhancing lesions and show a mass effect on MRI CNS lymphoma Incorrect CNS lymphoma are common with AIDS, but associated with ring-enhancing lesions and show a mass effect on MRI Brain abscess Incorrect Brain abscess are common with AIDS, but associated with ring-enhancing lesions and show a mass effect on MRI HIV encephalopathy Incorrect usually present with dementia as the predominant symptom. Focal neurological deficits are not characteristics of this disease. MRI findings may be similar to PML put usually tends to be symmetrical Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection seen in immunocompromised patients. It is caused by JC virus, a human polyomavirus. PML predominantly involves the cortical white matter, but the brainstem and cerebellum may also be involved. The lesion typically doesn’t produce mass effect, and has a gradual onset of the symptoms. The most common presenting symptoms are hemipariesis and disturbances in speech, vision, and gait. An immunocompromised patient with focal neurological deficits should raise the suspicion for PML, and diagnosis is best confirmed with MRI. Classic MRI findings of PML consist of multiple demyelinating, non enhancing lesions with no mass effect. There is no effective treatment for PML, and the mean duration of survival from the time of diagnosis is six months.<br/> '''Educational Objective:''' <br/> '''References:''' A Infectious Disease 2020-10-28T01:27:47Z 2459150.5609607 WBR0710