]> 2026-07-31T14:08:25+00:00 WBR0703 0 en Familial Incorrect Rash to ampicillin doesn’t represent familial predisposition Viral exanthema Incorrect Viral exanthema usually observed during active viral infections Immediate hypersensitivity Incorrect The rash doesn’t represent immediate hypersensitivity to ampicilline Delayed hypersensitivity Incorrect The rash doesn’t represent delayed hypersensitivity to ampicilline Immune complexes Correct Circulating IgG and IgM antibodies targeting penicillin derivatives is the cause of the well known ampicilline-associated maculopapular rash phenomenon in patients with infectious mononucleosis Ampicilline-associated maculopapular rash in patients with infectious mononucleosis is a well know phenomenon. It is caused by the circulating IgG and IgM targeting penicillin derivatives causing this immune vasculitic rash<br/> '''Educational Objective:''' <br/> '''References:''' Emergency Room 19 year old boy present to the ER with generalized rash, he had fever and sore throat one week ago and got antibiotic prescription from his primary care physician 4 days ago. His past medical history is insignificant. He doesn’t smoke or consume recreational drugs or alcohol. He is sexually active with one partner and uses condoms regularly. Vital signs are normal except for temperature of 37.8 C(100 F). His physical examination reveals generalized maculopapular rash and posterior cervical lymphadenopathy. What is the most likely mechanism of rash development in that patient? E Infectious Disease 2020-10-28T01:26:37Z 2459150.5601505 WBR0703