]> 2026-07-31T14:08:24+00:00 WBR0649 0 en Increased hemoglobin breakdown Increased hemoglobin breakdown is seen in patients with hemolysis. Our patient's CBC, retic count and blood smear showed no indication of hemolysis. Increased hemoglobin breakdown is not seen in Crigler-Najjar type 1. Absent UDP-Glucuronyltransferase UDP-Glucuronyltransferase is absent or defective in Crigler-Najjar syndrome. The presentation of the patient is typical of this disease. Decreased bilirubin uptake by the liver Decreased bilirubin uptake by the liver is the main mechanism behind Gilbert syndrome not Crigler-Najjar. Bile outlet obstruction Bile outlet obstruction would usually lead to conjugated hyperbilirubinemia with deranged LFTs. Hydrolysis of conjugated bilirubin Hydrolysis of conjugated bilirubin is one of the mechanisms of neonatal hyperbilirubinemia. Biochemistry A 2-week-old child is brought to the neonatal care clinic for irritability and poor feeding. The mother also reports that she has noticed her child's eyes are unusually yellow. On physical examination, you notice that the child is poorly responsive and is markedly icteric and jaundiced. Lab tests ordered show normal liver function tests. Serum bilirubin levels is detected to be 28 mg/dL with absent conjugated bilirubin from the serum. Which of the following mechanisms is most likely responsible for this patient's presentation? B Gastrointestinal 2020-10-28T01:19:33Z 2459150.5552431 WBR0649