]> 2026-07-31T09:41:41+00:00 WBR0602 0 en Systemic lupus erythematosus Incorrect. Systemic lupus erythematosus is a systemic autoimmune disorder that can affect any part of the body. It commonly affects the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Features include a characteristic malar rash, photosensitivity, arthritis, Immunological tests reveals a positive anti-Smith, anti-ds DNA, antiphospholipid antibody, and/or false positive serological test for syphilis. Treatment involves the use of corticosteroids, antimalarials, and immunosuppressants. Inflammatory bowel disease Incorrect. Inflammatory bowel disease is a group of inflammatory conditions affecting mainly the colon and the small intestine. The major types of IBD are Crohn's disease and ulcerative colitis. Symptoms include: abdominal pain, vomiting, diarrhea, rectal bleeding, severe internal cramps/muscle spasms in the region of the pelvis and weight loss. Anemia is the most prevalent extra-intestinal complication of inflammatory bowel disease. Other extra-intestinal manifestations include: arthritis, pyoderma gangrenosum, primary sclerosing cholangitis, and non-thyroidal illness syndrome (NTIS). Diagnosis is generally by assessment of inflammatory markers in stool followed by colonoscopy with biopsy of pathological lesions. Treatment is with mesalazine, prednisone, TNF inhibitors (e.g., etanercept), azathioprine, methotrexate, or 6-mercaptopurine. Behçet's disease Correct. Behçet's disease a.k.a. Behçet's syndrome is a chronic multi-systemic vasculitis characterized by mucocutaneous, articular, neurological, gastrointestinal and ocular lesions. It involves a triad of symptoms that include recurring mouth ulcers (aphthous ulcers, canker sores), genital ulcers, and uveitis. Antiphopholipid syndrome Incorrect. Antiphopholipid syndrome is an autoimmune disease in which "antiphospholipid antibodies" (anti-cardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Common manifestation include: recurrent venous or arterial thrombosis and/or fetal loss. Amyloidosis Incorrect. Amyloidosis is a group of diseases resulting from abnormal deposition of amyloid protein in various tissues of the body. Amyloidosis can be systemic or organ specific. It could affect all the organs in the body. Symptoms depend on the organs affected by the deposits. These organs can include the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. Behçet's disease a.k.a. Behçet's syndrome is a chronic multi-systemic vasculitis characterized by mucocutaneous, articular, neurological, gastrointestinal and ocular lesions. It involves a triad of symptoms that include recurring mouth ulcers (aphthous ulcers, canker sores), genital ulcers, and uveitis. Other ocular manifestations include iridocyclitis, retinal and choroidal vasculitis, optic neuritis and retinal vascular occlusion. It is common among Turkey, Asia and Middle-east population, and usually affects people in the 2nd and third decade of life. The underlying pathology is caused by an overactive immune system without an apparent infection. It is diagnosed according to the International Study Group diagnostic guidelines: The presence of oral (aphthous) ulcers (any shape, size or number at least 3 times in any 12 months) plus 2 out of the next 4 "hallmark" symptoms: - Genital ulcers (including anal ulcers and spots in the genital region and swollen testicles or epididymitis in men), - Skin lesions (papulo-pustules, folliculitis, erythema nodosum, acne in post-adolescents not on corticosteroids), - Eye inflammation (iritis, uveitis, retinal vasculitis, cells in the vitreous), - Pathergy reaction (papule >2 mm dia. 24-48 hrs or more after needle-prick) The current treatment is aimed at reducing the symptoms. Anti-inflammatory agents such as infliximab, etanercept which are anti-TNF agents and other drugs like interferon alfa-2a, azathioprine, colchicine, thalidomide, dapsone and rebamipide are useful alternatives. Educational Objective: A history of recurrent mouth ulcers (aphthous ulcers, canker sores), genital ulcers, and uveitis is highly suggestive of Behçet's disease which is common among the Turkish, Asian, and middle-east population. It is a multi-systemic inflammatory disorder, and treated with anti-inflammatory agents and immunosuppressants.<br/> '''Educational Objective:''' <br/> '''References:''' Internal medicine C Allergy/Immunology 2020-10-28T01:08:57Z 2459150.5478819 WBR0602