]> 2026-07-31T11:51:05+00:00 WBR0601 0 en Brain cells Brain cells take up glucose through the activity of GLUT-1 (Glucose Transporter-1) Liver cells Liver cells take up glucose through the activity of GLUT-2 Skeletal muscle Skeletal muscle contains GLUT-4 but they require the action of insulin for glucose uptake Kidney Liver cells take up glucose through the activity of GLUT-4 Red blood cells Liver cells take up glucose through the activity of GLUT-4 Insulin is an anabolic hormone produced in the beta cells of the pancreas. It is involved in numerous processes in the body, such as fatty acid synthesis, protein synthesis, and glucose metabolism. In glucose metabolism, insulin is needed for the transport of glucose into cells in skeletal muscles and adipose tissue. Some organs (brain, RBCs, intestine, cornea, kidney, liver, and beta islet cells of the pancreas) do not require insulin for glucose uptake. <br> Glucose transporters are required for uptake of glucose into many organs. There are several subtypes of glucose transporters:<br> *GLUT-1: RBCs, brain cells, cornea<br> *GLUT-2 - Has bidirectional activity: Renal tubular cells, small intestinal epithelial cells, liver cells, and pancreatic beta cells<br> *GLUT-3: Neurons, placenta<br> *GLUT-4 – Insulin-responsive transport: Skeletal muscle, adipose tissue *GLUT-5: Intestinal epithelium<br/> '''Educational Objective:''' In glucose metabolism, insulin is needed for the transport of glucose into cells in skeletal muscles and adipose tissue. Some organs (brain, RBCs, intestine, cornea, kidney, liver, and beta islet cells of the pancreas) do not require insulin for glucose uptake.<br/> '''References:''' First Aid 2015 page 314 Physiology A 58-year-old woman recently diagnosed type 2 diabetes mellitus presents to the clinic for follow-up of her blood glucose concentration. Her fasting glycemia is 81 mg/dL (4.5 mmol/L) and she is doing well on diet and exercise alone. The patient asks about her need for insulin therapy and how insulin is involved in metabolism. Which of the following cells requires insulin for glucose uptake? C Endocrine 2020-10-28T01:08:47Z 2459150.5477662 WBR0601