]> 2026-07-31T11:52:04+00:00 WBR0590 0 en Reduction in glutamate release from the STN and GABA release from the GPi Reduction in glutamate release from the STN and increase in GABA release from the GPi GABA release from the GPi is reduced following the reduction in subthalamic excitability. Increase in glutamate release from the STN and increase in GABA release from GPi Release of both glutamate is reduced following the reduction in subthalamic excitability. Consequently, the GPi stimulation is reduced, which results in a reduced concentration of GABA. Increase in glutamate release from the STN and reduction in GABA release from the GPi Glutamate release is reduced following the reduction in subthalamic excitability. Reduction in glutamate release from the STN with no change in GABA release from the GPi GABA release is reduced following the reduction in subthalamic excitability. Anatomy Physiology Deep brain stimulation (DBS) is an invasive therapeutic procedure indicated for advanced Parkinson's disease. It consists of the surgical implantation of a device that sends high frequency electrical impulses into areas of the basal ganglia, particularly the subthalamic nucleus (STN) and the globus pallidus internus (GPi). It is hypothesized that the mechanism by which DBS improves parkinsonism symptoms includes hyperpolarization in the STN by DBS, which results in a reduction in the subthalamic excitability. Which of the following changes in neurotransmitter release is the result of the reduction in subthalamic excitability? A Neurology 2020-10-28T01:04:11Z 2459150.5445718 WBR0590