]> 2026-07-31T09:41:17+00:00 WBR0574 0 en Genetic predisposition Excessive caffeine consumption Cerebellar lesion Intention tremor secondary to a cerebellar lesion is characterized by a slow, coarse, and zigzag motion that is observed when the patient is reaching for a target (eg finger-to-nose testing). Intention tremor becomes more prominent as the patient approaches the desired object, often missing the actual location. Intention tremor may be either bilateral or unilateral depending of the location of the cerebellar lesion. Dopamine depletion from the substantia nigra Caudate atrophy Pathophysiology A 66-year-old woman, who had a recent hip fracture after a fall, presents to the neurology clinic with complaints of hand tremor for the past few months. Although the tremor has not significantly worsened over time, the patient explains that it is very bothersome and interferes with her daily activities. The patient notices the tremor only when she performs activities that require use of her arms. On physical examination, the physician notes an absence of a baseline tremor; but when the patient is asked to reach for a pen, she exhibits a slow, coarse, zigzag motion of her hand as she extends for it. The tremor increases in intensity as the patient’s hand gets closer to the object. Also, the patient often overshoots and often requires a few attempts before grabbing the pen. What is the most likely cause of this patient's tremor? C Neurology 2020-10-28T01:00:17Z 2459150.5418634 WBR0574