<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE rdf:RDF[
	<!ENTITY rdf 'http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
	<!ENTITY rdfs 'http://www.w3.org/2000/01/rdf-schema#'>
	<!ENTITY owl 'http://www.w3.org/2002/07/owl#'>
	<!ENTITY swivt 'http://semantic-mediawiki.org/swivt/1.0#'>
	<!ENTITY wiki 'https://www.wikidoc.org/index.php/Special:URIResolver/'>
	<!ENTITY category 'https://www.wikidoc.org/index.php/Special:URIResolver/Category-3A'>
	<!ENTITY property 'https://www.wikidoc.org/index.php/Special:URIResolver/Property-3A'>
	<!ENTITY wikiurl 'https://www.wikidoc.org/index.php/'>
]>

<rdf:RDF
	xmlns:rdf="&rdf;"
	xmlns:rdfs="&rdfs;"
	xmlns:owl ="&owl;"
	xmlns:swivt="&swivt;"
	xmlns:wiki="&wiki;"
	xmlns:category="&category;"
	xmlns:property="&property;">

	<owl:Ontology rdf:about="https://www.wikidoc.org/index.php/Special:ExportRDF/WBR0537">
		<swivt:creationDate rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2026-07-31T12:17:05+00:00</swivt:creationDate>
		<owl:imports rdf:resource="http://semantic-mediawiki.org/swivt/1.0"/>
	</owl:Ontology>
	<swivt:Subject rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/WBR0537">
		<rdf:type rdf:resource="https://www.wikidoc.org/index.php/Special:URIResolver/Category-3AWBRQuestion"/>
		<rdf:type rdf:resource="https://www.wikidoc.org/index.php/Special:URIResolver/Category-3APages_using_duplicate_arguments_in_template_calls"/>
		<rdfs:label>WBR0537</rdfs:label>
		<rdfs:isDefinedBy rdf:resource="https://www.wikidoc.org/index.php/Special:ExportRDF/WBR0537"/>
		<swivt:page rdf:resource="https://www.wikidoc.org/index.php/WBR0537"/>
		<swivt:wikiNamespace rdf:datatype="http://www.w3.org/2001/XMLSchema#integer">0</swivt:wikiNamespace>
		<swivt:wikiPageContentLanguage rdf:datatype="http://www.w3.org/2001/XMLSchema#string">en</swivt:wikiPageContentLanguage>
		<property:AnswerA rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Increased HR, increased BP, increased CBF, and increased BDm</property:AnswerA>
		<property:AnswerAExp rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ketamine administration results in increased HR, increased BP, increased CBF, and increased BDm.</property:AnswerAExp>
		<property:AnswerB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Increased HR, decreased BP, increased CBF, and increased BDm</property:AnswerB>
		<property:AnswerBExp rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BP increases following ketamine infusion.</property:AnswerBExp>
		<property:AnswerC rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Increased HR, decreased BP, increased CBF, and decreased BDm</property:AnswerC>
		<property:AnswerCExp rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BP and BDm increase following ketamine infusion.</property:AnswerCExp>
		<property:AnswerD rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Increased HR, decreased BP, decreased CBF, and decreased BDm</property:AnswerD>
		<property:AnswerDExp rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BP, CBF, and BDm increase following ketamine infusion.</property:AnswerDExp>
		<property:AnswerE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Decreased HR, increased BP, increased CBF, and increased BDm</property:AnswerE>
		<property:AnswerEExp rdf:datatype="http://www.w3.org/2001/XMLSchema#string">HR increases following ketamine infusion.</property:AnswerEExp>
		<property:Approved rdf:resource="&wiki;Yes"/>
		<property:ExamType rdf:resource="&wiki;USMLE_Step_1"/>
		<property:Explanation rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ketamine is a phencyclidine (PCP) analog used as an intravenous anesthetic drug.  Ketamine acts as a non-competitive N-methyl-D-aspartate (NMDA) receptor blocker.  Ketamine is known to cause dissociative anesthesia, a state of profound analgesia with only superficial sleep and spontaneous ventilation.  It does not usually suppress respiratory drive unless used at very high doses.  

Because ketamine increases intracranial pressure, it is contraindicated among patients with brain injury.  Other systemic effects of ketamine are generally also increased. Following ketamine, there is an increased heart rate, blood pressure, CVP, CO2 baroreceptor function, bronchodilation, respiratory rate, uterine tone, salivation.&lt;br/&gt;
'''Educational Objective:''' Ketamine causes systemic effects by stimulating hemodynamic and respiratory systems. Following ketamine, there is an increased heart rate, blood pressure, cerebral blood flow, CVP, CO2 baroreceptor function, bronchodilation, respiratory rate, uterine tone, salivation.&lt;br/&gt;
'''References:''' Stevenson C. Ketamine: a review. Update in Anaesthesia. 2005;20:25-9.</property:Explanation>
		<property:MainCategory rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pharmacology</property:MainCategory>
		<property:Page_has_default_form rdf:resource="&wiki;WBRQuestion"/>
		<property:Prompt rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A researcher is studying the hemodynamic and respiratory effects of intravenous anesthetics.  In one experiment, he injects a mouse with intravenous ketamine infusion.  Several minutes later, he measures the mouse's heart rate (HR), blood pressure (BP), cerebral blood flow (CBF), and bronchial diameter (BDm) to assess the cardiovascular and respiratory roles of ketamine.  Which of the following hemodynamic and respiratory changes are most likely to occur following ketamine infusion in this experiment?</property:Prompt>
		<property:RightAnswer rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A</property:RightAnswer>
		<property:SubCategory rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neurology</property:SubCategory>
		<property:WBRKeyword rdf:resource="&wiki;Saliva"/>
		<property:WBRKeyword rdf:resource="&wiki;Ketamine"/>
		<property:WBRKeyword rdf:resource="&wiki;Cerebral_blood_flow"/>
		<property:WBRKeyword rdf:resource="&wiki;Bronchodilator"/>
		<property:WBRKeyword rdf:resource="&wiki;Respiratory_system"/>
		<property:WBRKeyword rdf:resource="&wiki;Analgesic"/>
		<property:WBRKeyword rdf:resource="&wiki;Adverse_effect_-28medicine-29"/>
		<property:WBRKeyword rdf:resource="&wiki;Dissociative_drug"/>
		<property:WBRKeyword rdf:resource="&wiki;Heart_rate"/>
		<property:WBRKeyword rdf:resource="&wiki;Anesthesia"/>
		<property:WBRKeyword rdf:resource="&wiki;Hemodynamics"/>
		<property:WBRKeyword rdf:resource="&wiki;Respiratory_rate"/>
		<property:WBRKeyword rdf:resource="&wiki;Drug"/>
		<property:WBRKeyword rdf:resource="&wiki;CVP"/>
		<property:WBRKeyword rdf:resource="&wiki;Uterine_tone"/>
		<swivt:wikiPageModificationDate rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-28T00:53:29Z</swivt:wikiPageModificationDate>
		<property:Modification_date-23aux rdf:datatype="http://www.w3.org/2001/XMLSchema#double">2459150.5371412</property:Modification_date-23aux>
		<swivt:wikiPageSortKey rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WBR0537</swivt:wikiPageSortKey>
	</swivt:Subject>
	<owl:DatatypeProperty rdf:about="http://semantic-mediawiki.org/swivt/1.0#creationDate" />
	<owl:Class rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Category-3AWBRQuestion" />
	<owl:Class rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Category-3APages_using_duplicate_arguments_in_template_calls" />
	<owl:ObjectProperty rdf:about="http://semantic-mediawiki.org/swivt/1.0#page" />
	<owl:DatatypeProperty rdf:about="http://semantic-mediawiki.org/swivt/1.0#wikiNamespace" />
	<owl:DatatypeProperty rdf:about="http://semantic-mediawiki.org/swivt/1.0#wikiPageContentLanguage" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerA" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerAExp" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerB" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerBExp" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerC" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerCExp" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerD" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerDExp" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerE" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AAnswerEExp" />
	<owl:ObjectProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AApproved" />
	<owl:ObjectProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AExamType" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AExplanation" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AMainCategory" />
	<owl:ObjectProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3APage_has_default_form" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3APrompt" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3ARightAnswer" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3ASubCategory" />
	<owl:ObjectProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AWBRKeyword" />
	<owl:DatatypeProperty rdf:about="http://semantic-mediawiki.org/swivt/1.0#wikiPageModificationDate" />
	<owl:DatatypeProperty rdf:about="https://www.wikidoc.org/index.php/Special:URIResolver/Property-3AModification_date-23aux" />
	<owl:DatatypeProperty rdf:about="http://semantic-mediawiki.org/swivt/1.0#wikiPageSortKey" />
	<!-- Created by Semantic MediaWiki, https://www.semantic-mediawiki.org/ -->
</rdf:RDF>