]> 2026-07-31T11:50:52+00:00 WBR0488 0 en Intrinsic tyrosine kinase Insulin and growth factors, such as IGF-1, FGF, and PDGF, have receptors with an intrinsic tyrosine kinase activity. Receptor-associated tyrosine kinase G-protein coupled receptor Alpha and beta adrenergic receptors are 2 examples of G-protein coupled receptors. Intracellular steroid receptor Receptors for vitamin D, thyroid hormones (T3 and T4), cortisol, aldosterone, and sex hormones (estrogen, progesterone, and testosterone) are intracellular steroid receptors. Inositol triphosphate receptor Receptors for oxytocin, TRH, Histamine-1 (H1), arginine vasopressor receptor-1 (V1), angiotensin II, and gastrin are inositol triphosphate (IP3) receptors. Pathophysiology A 62-year-old man presents to the physician's office with worsening pruritus for the past 3 months. He reports that his pruritus becomes much worse following a hot shower. On review of systems, the patient also complains of recurrent headaches for the past few weeks. His temperature is 37.1 °C (98.8 °F), blood pressure is 165/92 mmHg, and heart rate is 88/min. Physical examination is remarkable for facial plethora, engorged conjunctival veins, and splenomegaly palpated 3 cm below costal margin. Further investigation reveals hemoglobin of 18.8 g/dL and undetectable serum erythropoietin levels. The physician suspects a genetic disorder and confirms the diagnosis with genetic testing. Which of the following receptor types is most likely involved in this patient's condition? B Hematology 2020-10-28T00:44:14Z 2459150.5307176 WBR0488