]> 2026-07-31T11:51:09+00:00 WBR0487 0 en Microtubule stabilization Paclitaxel is a microtubule stabilizer that is not effective for the management of CML. Inhibition of DNA polymerase Cytarabine is a pyrmidine analog that inhibits DNA polymerase. It is not effective for the management of CML. Inhibition of dihydrofolate reductase Methotrexate is a folic acid analog that inhibits dihydrofolate reductase to decrease DNA and protein synthesis. It is not effective for the management of CML. Inhibition of topoisomerase I Irinotecan and topotecan inhibit topoisomerase I and prevent the unwinding and replication of DNA. Inhibition of protein kinase Tyrosine kinase inhibitors, such as imatinib, are effective for the management of CML. Pathophysiology A 36-year-old woman presents to the physician's office with complaints of chronic fatigue and decreased exercise tolerance. She explains that over the past 4 months, these symptoms have became increasingly intolerable. Upon physical examination, the physician notes a mild splenomegaly. The results from the ordered lab tests are illustrated below. The patient's diagnosis is then confirmed and chemotherapy is initiated. What is the mechanism of action of the drug most likely administered to this patient? Hb = 9.0 g/dL<br> Hct = 27.2 %<br> MCV = 82 fL<br> Plt = 120 x 10⁹/L<br> WBCs = 56000 / mm³<br> %Neutrophils = 96 %<br> %Lymphocytes = 2 %<br> Vitamin B12 level: Elevated<br> Leukocyte alkaline phosphatase: Low E Oncology 2020-10-28T00:44:04Z 2459150.5306019 WBR0487