]> 2026-07-31T09:41:28+00:00 WBR0485 0 en Alpha globin gene mutation Beta-globin gene mutation ''ALAS2'' mutation ''Spectrin'' and ''ankyrin'' mutations ''G6PD'' mutation ''G6PD'' gene mutation results in glucose-6-phosphate dehydrogenase (G6PD) deficiency that causes a decrease in glutathione and an increased susceptibility to oxidant stress. Patients present with back pain, dark-colored urine, and severe pallor following exposure to triggers, such as fava beans intake, infections, or drugs. Labs typically demonstrate anemia and hemoglobinuria. Peripheral smear shows RBCs with Heinz bodies and bite cells. Pathology Pathophysiology C Hematology 2020-10-28T00:43:44Z 2459150.5303704 WBR0485