]> 2026-07-31T14:08:25+00:00 WBR0476 0 en IgG antibodies against cadherins IgM antibodies against desmosomes IgG antibodies against hemidesmosomes Bullous pemphigoid is an autoimmune disorder that results from IgG auto-antibodies against hemidesmosomes. Unlike pemphigus vulgaris, bullous pemphigoid is not life-threatening. To distinguish both conditions, bullous pemphigoid is characterized by IgG antibodies in the epidermal basement membrane, while PV is characterized by intraepidermal IgG antibodies. Also, immunofluorescence in bullous pemphigoid demonstrates a linear pattern at the epidermal-dermal junction, while it demonstrates a net-like or reticular pattern in pemphigus vulgaris. IgM antibodies against hemidesmosomes IgE antibodies against hemidesmosomes Pemphigus vulgaris does not result from auto-antibodies against hemidesmosomes. Also, bullous pemphigoid is caused by IgG antibodies against hemidesmosomes, not IgE antibodies. Pathophysiology A 50-year-old woman presents to her dermatologist with complaints of multiple skin lesions. Physical examination is remarkable for flaccid skin blisters. The upper epidermal layer is easily removed with manual stroking or gentle pressure. Immunofluorescence demonstrates antibodies surrounding the cells in a net-like pattern. Which of the following processes best characterizes the patient's disease? A Dermatology 2020-10-28T00:42:14Z 2459150.5293287 WBR0476