]> 2026-07-31T11:51:07+00:00 WBR0430 0 en BUN/creatinine ratio Serum β2 microglobulin and albumin concentrations Serum β2 microglobulin and albumin concentrations are used by the ISS for staging multiple myeloma. Serum CA-125 concentration Serum CA-125 concentration may be helpful in the diagnosis and follow-up of patients with ovarian cancer. Serum calcium concentration Multiple myeloma causes lytic lesions in the bone, which releases calcium stored in bone. However, serum calcium concentratiaon is not used for the staging of multiple myeloma. Spread to lymph nodes The majority of solid tumors are staged with the classical TNM staging system. However, multiple myeloma is not staged by the classical TNM staging system, and spread to lymph node is not useful in the staging of multiple myeloma. Pathology A 78-year-old man presents to the physician’s office with complaints of back pain and fatigue for the past few weeks. The patient explains that unlike his previous pains, his current back pain awakens him at night and is not relieved by medications. Evaluation reveals normochromic normocytic anemia, elevated concentration of serum calcium, and renal insufficiency. Peripheral smear of the patient’s blood demonstrates rouleaux formation. Which of the following markers is most frequently used for the staging of the patient's condition? B Hematology Oncology 2020-10-28T00:32:08Z 2459150.5223148 WBR0430