]> 2026-07-31T11:52:04+00:00 WBR0327 0 en Increase in HbF levels Hydroxyurea is beneficial in patients with sickle cell disease (SCD) because it increases HbF levels. Decrease in thymidylate synthase activity 5-Fluorouracil is known to inhibit thymidylate synthase. Increase in ribonucleotide reductase activity Hydroxyurea inhibits ribonucleotide reductase, which is not beneficial to patients with SCD. Increase in HbA levels Patients with SCD have low HbA levels, but hydroxyurea is beneficial in patients with sickle cell disease (SCD) because it increases HbF levels. Systemic vasodilatory effect Vasodilation is helpful for patients with SCD, but is not the mechanism by which hydroxyurea is beneficial. The patient in this scenario is most likely diagnosed with sickle cell disease. Patients with sickle cell disease often require hydroxyurea, which provides symptomatic relief by increasing HbF levels. HbF has high affinity for oxygen and may aid in the delivery of oxygen to peripheral tissues in patients with SCD. Hydroxyurea is a chemotherapeutic agent that hinders ribonucleotide reductase ability to decrease DNA synthesis during S-phase. It is typically used to treat cancers, such as melanoma and CML. Common side effects of hydroxyurea include GI symptoms, bone marrow suppression, and an increased risk of developing leukemias.<br/> '''Educational Objective:''' Hydroxyurea often administered to patients with sickle cell disease in order to increase HbF levels.<br/> '''References:''' First Aid 2014 page 67 Pharmacology A 3-year-old African American boy is brought by his parents to the emergency department for irritability and swelling in the hands and feet. A thorough work-up reveals that the patient has a mutation in the hemoglobin gene that renders red blood cells susceptible to low oxygen tension. The attending physician explains to the mother that the child will likely need treatment with a chemotherapeutic agent to control his disorder. By which of the following mechanisms does this agent help relieve the patient's symptoms? A Hematology 2020-10-28T00:11:47Z 2459150.5081829 WBR0327