]> 2026-07-31T11:51:12+00:00 WBR0262 0 en Slit lamp examination of the eye Echocardiography '''Incorrect'''-Echocardiogram can only confirm the cardiomyopathy, but will not help to establish the diagnosis. Determination of serum copper '''Incorrect'''-Determination of serum copper will only be needed when Wilson’s disease is the probable cause of hepatic abnormalities. 24 hours urine cortisol Determination of iron saturation '''Correct'''-The most frequent cause of iron overload is a common genetic disorder (C282Y mutation of HFE gene) known as (idiopathic) hemochromatosis. Secondary iron storage problems can occur in a variety of anemias. The most practical screening test is the determination of serum iron, transferrin saturation, and plasma ferritin. Serum iron will be elevated and so will the plasma ferritin level. But increased ferritin value is less sensitive than increased transferrin saturation value, since they require greater degree of iron overload to increase the iron stores. So transferrin saturation >45% along with increased serum iron will be the most sensitive screening test. Community Medical Health Center Primary Care Office Inpatient Facilities Vendhan Ramanujam A 56 year old man complains of impotence. On physical examination, he looks obese with has an elevated jugular venous pressure, S3 gallop, hepatomegaly and a gray opaque ring in corneal margin of both the eyes. He also appears tanned, with pigmentation along joint folds. His left knee is swollen and tender. His blood pressure is 150/98 with a heart rate of 98/min. The liver enzymes are elevated and the plasma glucose is found to be 250 mg/dL. The next best investigation to establish the diagnosis will be E Hematology Genetics 2020-10-27T23:57:26Z 2459150.4982176 WBR0262