]> 2026-07-31T11:51:57+00:00 WBR0246 0 en C-kit Ret Expression of Ret protein is associated with multiple endocrine neoplasia (MEN) 2A and 2B syndromes. Braf Expression of Braf is associated with melanoma Ras Expression of Ras is associated with colon adenocarcinoma. C-myc Gastrointestinal stromal tumor (GIST) is a rare non-epithelial neoplasm of the GI tract, the mesentary, or the omentum. The majority of GIST tumors are spindle cell tumors that may be either malignant or benign. Most stromal tumors stain positively for C-Kit/CD117 (>90%), CD34, muscle-specific actin, smooth muscle actin, S-100, and desmin. Patients with GIST may be asymptomatic or have non-specific GI symptoms. This patient's symptoms of dull epigastric pain, fatigue, and weight loss, in conjunction with the CT finding of a mass in the stomach, are suggestive of malignancy. Characteristically, the pathogenesis of GIST tumors involves a gain-of-function mutation in the ''KIT'' proto-oncogene, which encodes a transmembrane receptor for stem cell factor that includes a tyrosine kinase component in its intracytoplasmic region.<br/> '''Educational Objective:''' Gastrointestinal stromal tumor (GIST) is a rare non-epithelial neoplasm of the GI tract, the mesentary, or the omentum. The majority of GIST tumors are spindle cell tumors that may be either malignant or benign. Most stromal tumors stain positively for C-Kit/CD117<br/> '''References:''' Din OS, Woll PJ. Treatment of gastrointestinal stromal tumor: focus on imatinib mesylate. Ther Clin Risk Manag. 2008;4(1):149-62.<br> First Aid 2014 page 232 Pathology A 62-year-old man presents to the physician's office with complaints of worsening abdominal pain over the past four months. The pain is described as dull and localized in the mid-epigastric region. The patient denies any association between his pain and food intake or posture. Upon further questioning, he describes symptoms of increasing fatigue and recent unintentional weight loss. An abdominal CT scan shows a gastric mass, and an endoscopy-guided biopsy of the mass reveals clusters of thin, elongated, spindle cells. Immunohistochemistry of this patient's tumor is most likely to reveal expression of which protein? A Gastrointestinal 2020-10-27T23:54:04Z 2459150.4958796 WBR0246