]> 2026-07-31T16:29:05+00:00 WBR0215 0 en Frequent neck examinations '''Incorrect'''-Frequent neck examinations is not sensitive enough to diagnose early medullary thyroid carcinoma. Annual physical examination '''Incorrect'''-Annual physical examination are not sensitive enough to diagnose early medullary thyroid carcinoma. Periodic calcium measurement '''Incorrect'''-Periodic calcium measurement is useful for screening patients with parathyroid hyperplasia in MEN I and MEN IIa. Periodic stimulated serum calcitonin measurement '''Incorrect'''-Periodic stimulated serum calcitonin measurement was previously used to diagnose early medullary thyroid carcinoma before the advent of genetic tests. It is a labor intensive and time consuming test. It is still used to identify residual medullary thyroid carcinoma after thyroidectomy. DNA testing '''Correct'''-The patient has features suggestive of MEN IIa, which is characterized by medullary thyroid carcinoma, pheochromocytoma as well as parathyroid hyperplasia. It is an autosomal dominant disorder arising from mutation in RET proto-oncogene localized in chromosome 10. Genetic testing can be easily carried out in peripheral blood sample by a sensitive PCR method that will identify the mutations. More than 95% have RET proto-oncogene mutation. Internal medicine Vendhan Ramanujam A 35 year old Caucasian male is diagnosed with medullary thyroid carcinoma that is non resectable. His past medical history is insignificant. He does not smoke or consume alcohol. His family history is significant for thyroid cancer and pheochromocytoma in his father. Which of the following could have been most effective in preventing this patient’s non resectable cancer? E Endocrine Preventive Medicine Genetics 2020-10-27T23:47:38Z 2459150.491412 WBR0215