]> 2026-07-31T09:41:42+00:00 WBR0205 0 en Lymphocytic infiltrate Lymphocytic infiltrates may be observed in brain biopsies of patients with encephalitis. Encephalitis is characterized by the presence of fever and a more rapid onset of symptoms. Alpha-synuclein deposits Alpha-synuclein deposits are observed in brain biopsies of patients with Lewy body dementia. Lewy body dementia is characterized by the presence of dementia, early parkinsonism, and visual hallucinations. Beta-pleated sheets Beta-pleated sheets are observed in brain biopsies of patients with Creutzfeldt-Jakob disease (CJD). Pick bodies Pick bodies are aggregates of tau proteins that are characteristic of Pick's disease. Patients with Pick's disease present with frontotemporal atrophy that causes dementia, parkinsonism, change in personality, and aphasia. Elevation of 14-3-3 protein in CSF is not typical in Pick's disease. Beta-amyloid deposits Beta-amyloid deposits correspond to the composition of senile plaques, which are pathological changes characteristic of Alzheimer disease. Manifestations of Alzheimer disease include slowly progressive dementia and late disability. The patient's symptoms are progressing relatively rapidly, which is not consistent with Alzheimer disease. Microbiology Pathology A 62-year-old woman is brought to the emergency department (ED) by her husband. He reports that one month ago, the patient had complaints of sleep disorder and decrease in appetite. A few days later, she started to become forgetful. At first, the patient was forgetting minor details like the car keys or appointments. The husband is now more concerned that she has lately been forgetting the names of her children, has developed slurred speech, and has experienced progressive difficulty in walking. The patient's temperature is 37 °C (98.6 °F), blood pressure is 122/82 mmHg, and heart rate is 76/min. Physical exam in the ED is remarkable for confusion, muscular hypokinesis, and atrophy. The physician also notes the presence of involuntary intermittent myoclonic jerks of the lower extremities in response to sound or touch. Cerebrospinal fluid analysis demonstrates elevated 14-3-3 proteins. Brain biopsy of this patient would most likely demonstrate which of the following findings? C Neurology Infectious Disease 2020-10-27T23:45:10Z 2459150.4896991 WBR0205