]> 2026-07-31T09:41:27+00:00 WBR0156 0 en Infliximab Reduced vitamin B9 Vitamin K Protamine sulfate Folic acid Folic acid (vitamin B9) may be administered routinely with methotrexate to reduce nausea and mouth ulcers associated with methotrexate administration. Unlike leucovorin, folic acid cannot overcome methotrexate-induced inhibition of the dihydrofolate reductase enzyme and is not helpful in severe adverse events. Pharmacology A 43-year-old woman presents to her primary care physician for severe joint pain and fatigue over the past three months. She complains of joint stiffness in the morning, which improves throughout the day. She describes her pain as a persistent, dull pain that “hurts all over”. On physical examination, the physician notes mild joint swelling around the knee and ulnar deviation of the fingers. Laboratory testing reveals a positive ELISA for anti-IgG antibodies. The patient is started on a first-line disease-modifying drug, but 2 years later is found to be critically leukopenic. Following appropriate work-up, the physician suspects the patient's leukopenia is a an adverse event associated with the drug. Which of the following medications can be used to quickly reverse the effects of the administered drug? B Musculoskeletal/Rheumatology 2020-10-27T23:32:13Z 2459150.480706 WBR0156