]> 2026-07-31T09:41:33+00:00 WBR0118 0 en 5'...ACA GCT TAG GGC CAT...3' This is a nonsense mutation due to replacement of C with G at the 3rd position of the 3rd codon. The mRNA sequence will be read in a 5' to 3' fashion, and it will thus be identical to the reference sequence shown in the vignette with the exception of U replacing T. Thus, the 3rd codon will be UAG, which is a stop codon that does not code for any amino acid but rather stops the process of mRNA transcription leading to a nonsense mutation. 5'...ACA GCT TAC GCC ATT...3' The deletion of G at the first position of the 4th codon in GGC causes a small frameshift mutation due to deletion of just 1 nucleotide. Small frameshift mutations account a smaller percentage of mutations that cause DMD. 5'...ACA CCT TAC GGC CAT...3' This is a missense mutation due to replacement of G at the first position of the second codon with C. 5'...ACA CAT TCC AAT ATC...3' 5'...AAA GCT TAC GGC CAT...3' This is a missense mutation due to replacement of C at the second position of the first codon with A. Genetics A 5-year-old boy is brought to the pediatrician's office by his parents for muscle weakness. The parents explain that when the child attempts to rise from the floor, he uses his hands and arms to “walk up” his own body. The boy undergoes genetic evaluation where portions of the ''DMD'' gene are subject to sanger sequencing of DNA. Assuming that all codons are exons of critical regions within the gene and the first three nucleotides constitute the first codon, which of the following DNA sequences is most likely to be observed in this patient? Reference Sequence: 5'...ACA GCT TAC GGC CAT...3' D Musculoskeletal/Rheumatology 2020-10-27T23:24:20Z 2459150.4752315 WBR0118