]> 2026-07-31T09:40:14+00:00 WBR0074 0 en Atovaquone Clindamycin For mild-to-moderate disease, alternative therapeutic regimens include: dapsone plus TMP, primaquine plus clindamycin, and atovaquone. However, clindamycin is not classically associated with hemolytic anemia. Methylprednisolone Patients with moderate-to-severe disease should receive adjunctive corticosteroids as early as possible and certainly within 72 hours after starting specific PCP therapy. However, methylprednisolone is not classically associated with hemolytic anemia. Pentamidine For moderate-to-severe disease, clindamycin-primaquine or pentamidine can be used. However, pentamidine generally is not classically associated with hemolytic anemia. Primaquine For mild-to-moderate disease, alternative therapeutic regimens include: dapsone plus TMP, primaquine plus clindamycin, and atovaquone. Common triggers of hemolytic anemia include sulfonamides and other drugs such as chloroquine, isoniazid, nalidixic acid, nitrofurantoin, and primaquine. Pharmacology Anonymous (Reviewed by Will Gibson and Yazan Daaboul) A 32-year-old homosexual intravenous drug user is admitted with a worsening respiratory distress accompanied by fever and nonproductive cough. Arterial blood gas values on room air are pH 7.52, PaCO2=28 mmHg, HCO3=22 mEq/L, and PaO2=70 mmHg. His CD4+ count is 150 cells/μl. Chest X-ray reveals bilateral perihilar interstitial infiltrates suggesting an infectious etiology. The causative organism is detected in bronchoalveolar lavage (BAL) with silver stain. The next day, he starts to have back pain, dizziness, headache, coldness in hands and feet, pale skin, and chest pain. Peripheral blood smear shows irregularly fragmented erythrocytes. Supravital stain of the smear shows immature red cells with dark blue dots and curved linear structures in the cytoplasm. Which of the following medications is most likely to be the cause of his symptoms? E Hematology 2020-10-27T23:15:06Z 2459150.4688194 WBR0074