WBR0247
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathology |
| Sub Category | SubCategory::Gastrointestinal |
| Prompt | [[Prompt::A 45 year old male patient, known to have a positive family history of colon cancer in his father at the age of 55, presents to his general practitioner for an annual checkup. His physician informs him that it is recommended that he undergoes a screening colonoscopy 10 years prior to the age his father had colon cancer. The patient asks the physisican about the etiology of colon cancer. His physician answers that most cases of colon cancer are sporadic while some are familial and they are related to mutations in some genes. Mutation in which of the following genes is associated with familial colon cancer?]] |
| Answer A | AnswerA::C-kit |
| Answer A Explanation | [[AnswerAExp::C-kit oncogene is associated with GIST.]] |
| Answer B | AnswerB::Ret |
| Answer B Explanation | [[AnswerBExp::Ret oncogene is associated with MEN syndrome type IIa and IIb.]] |
| Answer C | AnswerC::Abl |
| Answer C Explanation | [[AnswerCExp::Abl oncogene is associated with CML.]] |
| Answer D | AnswerD::Ras |
| Answer D Explanation | [[AnswerDExp::Ras oncogene is associated with colon carcinoma.]] |
| Answer E | AnswerE::C-myc |
| Answer E Explanation | [[AnswerEExp::C-myc is associated with Burkitt's lymphoma.]] |
| Right Answer | RightAnswer::D |
| Explanation | [[Explanation:: Educational Objective: |
| Approved | Approved::No |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |