Hospital-acquired pneumonia medical therapy

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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Philip Marcus, M.D., M.P.H.[2]

Overview

Antimicrobial therapy

Patients prone to Methicillin-resistant staphylococcus aureus

  • Critically ill patients
  • History of recent antibiotic therapy
  • Patient admitted in a hospital with increased incidence of MRSA.

Antibiotic choice for MRSA

Side-effects of Linezolid

Side-effects of vancomycin

Vancomycin trough

  • The Target vancomycin trough concentrations of 15 to 20 mcg/mL.

Supportive trial data [1]

In a study done in 1184 patients treated with linezolid and vancomycin no significant difference in 60 days mortality were found between the two groups. The side-effects profile were similar in both the groups however nephrotoxicity was commoner in the vancomycin group. Linezolid was found to be non-inferior to vancomycin for clinical outcome, and microbiologic outcome at end of treatment and end of study.

References

  1. Wunderink RG, Niederman MS, Kollef MH, Shorr AF, Kunkel MJ, Baruch A, McGee WT, Reisman A, Chastre J (2012). "Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study". Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 54 (5): 621–9. doi:10.1093/cid/cir895. PMID 22247123. Retrieved 2012-09-11. Unknown parameter |month= ignored (help)

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