UBTF
| Upstream binding transcription factor, RNA polymerase I | |||||||||||||
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File:PBB Protein UBTF image.jpg PDB rendering based on 1k99. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | UBTF ; NOR-90; UBF | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7970 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE UBTF 202692 s at tn.png | |||||||||||||
| File:PBB GE UBTF 214881 s at tn.png | |||||||||||||
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| Species | Human | Mouse | |||||||||||
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Upstream binding transcription factor, RNA polymerase I, also known as UBTF, is a human gene.[1]
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM][1]
References
Further reading
- Chan EK, Imai H, Hamel JC, Tan EM (1991). "Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor". J. Exp. Med. 174 (5): 1239–44. PMID 1940801.
- Jantzen HM, Admon A, Bell SP, Tjian R (1990). "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins". Nature. 344 (6269): 830–6. doi:10.1038/344830a0. PMID 2330041.
- Bell SP, Learned RM, Jantzen HM, Tjian R (1988). "Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis". Science. 241 (4870): 1192–7. PMID 3413483.
- Voit R, Kuhn A, Sander EE, Grummt I (1995). "Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF". Nucleic Acids Res. 23 (14): 2593–9. PMID 7651819.
- Hempel WM, Cavanaugh AH, Hannan RD; et al. (1996). "The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor". Mol. Cell. Biol. 16 (2): 557–63. PMID 8552083.
- Hanada K, Song CZ, Yamamoto K; et al. (1996). "RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription". EMBO J. 15 (9): 2217–26. PMID 8641287.
- Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator". J. Biol. Chem. 271 (31): 18767–74. PMID 8702533.
- Matera AG, Wu W, Imai H; et al. (1997). "Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 41 (1): 135–8. doi:10.1006/geno.1997.4647. PMID 9126496.
- Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes". Chromosoma. 106 (8): 493–502. PMID 9426281.
- Voit R, Hoffmann M, Grummt I (1999). "Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF". EMBO J. 18 (7): 1891–9. doi:10.1093/emboj/18.7.1891. PMID 10202152.
- Liu CJ, Wang H, Lengyel P (1999). "The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription". EMBO J. 18 (10): 2845–54. doi:10.1093/emboj/18.10.2845. PMID 10329630.
- Hannan KM, Hannan RD, Smith SD; et al. (2000). "Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1". Oncogene. 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. PMID 11042686.
- Kalousek I, Krízková P (2001). "Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF". Cell. Mol. Biol. (Noisy-le-grand). 46 (7): 1163–71. PMID 11075946.
- Pelletier G, Stefanovsky VY, Faubladier M; et al. (2002). "Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription". Mol. Cell. 6 (5): 1059–66. PMID 11106745.
- Miller G, Panov KI, Friedrich JK; et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMID 11250903.
- Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I.". Biol. Chem. 382 (8): 1163–70. PMID 11592397.
- Voit R, Grummt I (2002). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMID 11698641.
- Stefanovsky VY, Pelletier G, Hannan R; et al. (2002). "An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF". Mol. Cell. 8 (5): 1063–73. PMID 11741541.
- Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.
- Dühr S, Torres-Montaner A, Astola A; et al. (2002). "Molecular analysis of the 5' region of human ribosomal transcription factor UBF". DNA Seq. 12 (4): 267–72. PMID 11916260.
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