SPA17

Sperm autoantigenic protein 17
Identifiers
Symbols	SPA17 ; SP17; SP17-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7951
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SPA17 205406 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sperm autoantigenic protein 17, also known as SPA17, is a human gene.

This gene encodes a protein present at the cell surface. Studies in rabbit suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbit suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.

Further reading

• McLeskey SB, Dowds C, Carballada R; et al. (1997). "Molecules involved in mammalian sperm-egg interaction". Int. Rev. Cytol. 177: 57–113. PMID 9378618.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Richardson RT, Yamasaki N, O'Rand MG (1994). "Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. doi:10.1006/dbio.1994.1285. PMID 7525387.CS1 maint: Multiple names: authors list (link)
• Kong M, Richardson RT, Widgren EE, O'Rand MG (1995). "Sequence and localization of the mouse sperm autoantigenic protein, Sp17". Biol. Reprod. 53 (3): 579–90. PMID 7578682.CS1 maint: Multiple names: authors list (link)
• Lea IA, Richardson RT, Widgren EE, O'Rand MG (1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim. Biophys. Acta. 1307 (3): 263–6. PMID 8688458.CS1 maint: Multiple names: authors list (link)
• Fujita A, Nakamura K, Kato T; et al. (2000). "Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella". J. Cell. Sci. 113 ( Pt 1): 103–12. PMID 10591629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wen Y, Richardson RT, Widgren EE, O'Rand MG (2001). "Characterization of Sp17: a ubiquitous three domain protein that binds heparin". Biochem. J. 357 (Pt 1): 25–31. PMID 11415432.CS1 maint: Multiple names: authors list (link)
• De Jong A, Buchli R, Robbins D (2003). "Characterization of sperm protein 17 in human somatic and neoplastic tissue". Cancer Lett. 186 (2): 201–9. PMID 12213290.CS1 maint: Multiple names: authors list (link)
• Buchli R, De Jong A, Robbins DL (2002). "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model". Biochim. Biophys. Acta. 1578 (1–3): 29–42. PMID 12393185.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding". Reproduction. 124 (6): 767–74. PMID 12530914.
• Takeoka Y, Kenny TP, Yago H; et al. (2004). "Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes". Dev. Immunol. 9 (2): 97–102. PMID 12739786.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiriva-Internati M, Wang Z, Pochopien S; et al. (2004). "Identification of a sperm protein 17 CTL epitope restricted by HLA-A1". Int. J. Cancer. 107 (5): 863–5. doi:10.1002/ijc.11486. PMID 14566839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Straughn JM, Shaw DR, Guerrero A; et al. (2004). "Expression of sperm protein 17 (Sp17) in ovarian cancer". Int. J. Cancer. 108 (6): 805–11. doi:10.1002/ijc.11617. PMID 14712480.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. Biol. Endocrinol. 2: 57. doi:10.1186/1477-7827-2-57. PMID 15257753.CS1 maint: Multiple names: authors list (link)
• Wang Z, Zhang Y, Ramsahoye B; et al. (2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer. 91 (8): 1597–603. doi:10.1038/sj.bjc.6602160. PMID 15381930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta G, Sharma R, Chattopadhyay TK; et al. (2007). "Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer". Int. J. Cancer. 120 (8): 1739–47. doi:10.1002/ijc.22463. PMID 17230514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)