SEMA3B

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Identifiers
Symbols	SEMA3B ; FLJ34863; LUCA-1; SEMA5; SEMAA; SemA; semaV
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20972
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SEMA3B 203071 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B, also known as SEMA3B, is a human gene.

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.

Further reading

• Püschel AW, Adams RH, Betz H (1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. PMID 7748561.CS1 maint: Multiple names: authors list (link)
• Wei MH, Latif F, Bader S; et al. (1996). "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG". Cancer Res. 56 (7): 1487–92. PMID 8603390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sekido Y, Bader S, Latif F; et al. (1996). "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns". Proc. Natl. Acad. Sci. U.S.A. 93 (9): 4120–5. PMID 8633026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi T, Nakamura F, Jin Z; et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
• Tomizawa Y, Sekido Y, Kondo M; et al. (2002). "Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13954–9. doi:10.1073/pnas.231490898. PMID 11717452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tse C, Xiang RH, Bracht T, Naylor SL (2002). "Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line". Cancer Res. 62 (2): 542–6. PMID 11809707.CS1 maint: Multiple names: authors list (link)
• Ochi K, Mori T, Toyama Y; et al. (2002). "Identification of semaphorin3B as a direct target of p53". Neoplasia. 4 (1): 82–7. doi:10.1038/sj/neo/7900211. PMID 11922394.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuroki T, Trapasso F, Yendamuri S; et al. (2003). "Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer". Cancer Res. 63 (12): 3352–5. PMID 12810670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castro-Rivera E, Ran S, Thorpe P, Minna JD (2004). "Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect". Proc. Natl. Acad. Sci. U.S.A. 101 (31): 11432–7. doi:10.1073/pnas.0403969101. PMID 15273288.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marsit CJ, Wiencke JK, Liu M, Kelsey KT (2005). "The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans". Carcinogenesis. 26 (8): 1446–9. doi:10.1093/carcin/bgi098. PMID 15831529.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nair PN, McArdle L, Cornell J; et al. (2007). "High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene". Cancer Genet. Cytogenet. 174 (2): 100–10. doi:10.1016/j.cancergencyto.2006.11.017. PMID 17452250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)