SCG3

Secretogranin III
Identifiers
Symbols	SCG3 ; FLJ90833; SGIII
External IDs	Template:MGI HomoloGene: 7526
Gene ontology
RNA expression pattern
File:PBB GE SCG3 219196 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Secretogranin III, also known as SCG3, is a human gene.

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.

Further reading

• Huttner WB, Gerdes HH, Rosa P (1991). "The granin (chromogranin/secretogranin) family". Trends Biochem. Sci. 16 (1): 27–30. PMID 2053134.CS1 maint: Multiple names: authors list (link)
• Ozawa H, Takata K (1996). "The granin family--its role in sorting and secretory granule formation". Cell Struct. Funct. 20 (6): 415–20. PMID 8825061.
• Dopazo A, Lovenberg TW, Danielson PE; et al. (1994). "Primary structure of mouse secretogranin III and its absence from deficient mice". J. Mol. Neurosci. 4 (4): 225–33. PMID 7917832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holthuis JC, Jansen EJ, Martens GJ (1996). "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway". J. Biol. Chem. 271 (30): 17755–60. PMID 8663421.CS1 maint: Multiple names: authors list (link)
• Rong YP, Liu F, Zeng LC; et al. (2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 411–7. PMID 12098761.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hosaka M, Watanabe T, Sakai Y; et al. (2003). "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells". Mol. Biol. Cell. 13 (10): 3388–99. doi:10.1091/mbc.02-03-0040. PMID 12388744.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakai Y, Hosaka M, Hira Y; et al. (2003). "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands". J. Histochem. Cytochem. 51 (2): 227–38. PMID 12533531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hosaka M, Suda M, Sakai Y; et al. (2004). "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.". J. Biol. Chem. 279 (5): 3627–34. doi:10.1074/jbc.M310104200. PMID 14597614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakai Y, Hosaka M, Yoshinaga A; et al. (2004). "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats". Arch. Histol. Cytol. 67 (1): 57–64. PMID 15125023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanabe A, Yanagiya T, Iida A; et al. (2007). "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity". J. Clin. Endocrinol. Metab. 92 (3): 1145–54. doi:10.1210/jc.2006-1808. PMID 17200173.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)