Reticulon 4

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Reticulon 4
File:PBB Protein RTN4 image.jpg
PDB rendering based on 2g31.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols RTN4 ; NSP; ASY; NI220/250; NOGO; NOGO-A; NSP-CL; Nbla00271; Nbla10545; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
External IDs Template:OMIM5 Template:MGI HomoloGene: 10743
RNA expression pattern
File:PBB GE RTN4 211509 s at tn.png
File:PBB GE RTN4 210968 s at tn.png
File:PBB GE RTN4 214629 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Reticulon 4, also known as RTN4, is a human gene.[1]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: RTN4 reticulon 4".

Further reading

  • Ng CE, Tang BL (2002). "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration". J. Neurosci. Res. 67 (5): 559–65. PMID 11891768.
  • Watari A, Yutsudo M (2003). "Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration". Apoptosis. 8 (1): 5–9. PMID 12510146.
  • Schweigreiter R, Bandtlow CE (2006). "Nogo in the injured spinal cord". J. Neurotrauma. 23 (3–4): 384–96. doi:10.1089/neu.2006.23.384. PMID 16629624.
  • Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.
  • Prinjha R, Moore SE, Vinson M; et al. (2000). "Inhibitor of neurite outgrowth in humans". Nature. 403 (6768): 383–4. doi:10.1038/35000287. PMID 10667780.
  • Chen MS, Huber AB, van der Haar ME; et al. (2000). "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1". Nature. 403 (6768): 434–9. doi:10.1038/35000219. PMID 10667796.
  • GrandPré T, Nakamura F, Vartanian T, Strittmatter SM (2000). "Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein". Nature. 403 (6768): 439–44. doi:10.1038/35000226. PMID 10667797.
  • Yang J, Yu L, Bi AD, Zhao SY (2000). "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (1–2): 101–2. PMID 10773680.
  • Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Tagami S, Eguchi Y, Kinoshita M; et al. (2001). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity". Oncogene. 19 (50): 5736–46. doi:10.1038/sj.onc.1203948. PMID 11126360.
  • Fournier AE, GrandPre T, Strittmatter SM (2001). "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration". Nature. 409 (6818): 341–6. doi:10.1038/35053072. PMID 11201742.
  • Josephson A, Widenfalk J, Widmer HW; et al. (2001). "NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury". Exp. Neurol. 169 (2): 319–28. doi:10.1006/exnr.2001.7659. PMID 11358445.
  • Zhou ZM, Sha JH, Li JM; et al. (2002). "Expression of a novel reticulon-like gene in human testis". Reproduction. 123 (2): 227–34. PMID 11866689.
  • GrandPré T, Li S, Strittmatter SM (2002). "Nogo-66 receptor antagonist peptide promotes axonal regeneration". Nature. 417 (6888): 547–51. doi:10.1038/417547a. PMID 12037567.
  • Hu WH, Hausmann ON, Yan MS; et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. PMID 12067236.
  • Liu BP, Fournier A, GrandPré T, Strittmatter SM (2002). "Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor". Science. 297 (5584): 1190–3. doi:10.1126/science.1073031. PMID 12089450.
  • Dupuis L, Gonzalez de Aguilar JL, di Scala F; et al. (2002). "Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis". Neurobiol. Dis. 10 (3): 358–65. PMID 12270696.
  • Taketomi M, Kinoshita N, Kimura K; et al. (2002). "Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules". Neurosci. Lett. 332 (1): 37–40. PMID 12377379.
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